Tohru Yamada

7301010, Nov 27, 2007

May 19, 2006

11/436591

Ananda Chakrabarty - Villa Park IL, US
Tapas Das Gupta - River Forest IL, US
Tohru Yamada - Oak Park IL, US
Anita Chaudhari - Clifton Park NY, US
Arsenio Fialho - Lisbon, PT
Chang Soo Hong - Chicago IL, US

The Board of Trustees of the University of Illinois - Urbana IL

C07K 14/00
A61K 38/00

530350, 514 2

The present invention relates to cupredoxin, specifically azurin, and/or cytochrome Cand their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.

7338766, Mar 4, 2008

May 19, 2006

11/436590

Ananda Chakrabarty - Villa Park IL, US
Tapas Das Gupta - River Forest IL, US
Tohru Yamada - Oak Park IL, US
Anita Chaudhari - Clifton Park NY, US
Arsenio Fialho - Lisbon, PT
Chang Soo Hong - Chicago IL, US

The Board of Trustees of the University of Illinois - Urbana IL

C12Q 1/68
C12P 21/04
A61K 38/00
A61K 38/44
C07K 14/445

435 6, 435 697, 4352581, 4352582, 4241851, 424 944, 514 2, 514 12, 530300, 530350

The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.

7381701, Jun 3, 2008

May 19, 2006

11/436592

Ananda Chakrabarty - Villa Park IL, US
Tapas Das Gupta - River Forest IL, US
Tohru Yamada - Oak Park IL, US
Anita Chaudhari - Clifton Park NY, US
Arsenio Fialho - Lisbon, PT
Yonghua Zhu - Chicago IL, US

The Borad of Trustees of the University of Illinois - Urbana IL

A61K 38/00
C07K 7/00
C07K 14/00

514 2, 530324, 530326

The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals.

7491394, Feb 17, 2009

Nov 24, 2003

10/720603

Ananda M. Chakrabarty - Villa Park IL, US
Tapas K. Das Gupta - River Forest IL, US
Vasu Punj - Chicago IL, US
Olga Zaborina - Brookfield IL, US
Yoshinori Hiraoka - Chicago IL, US
Tohru Yamada - Oak Park IL, US

The Board of Trustees of the University of Illinois - Urbana IL

A61K 39/00
A61K 38/00
C12Q 1/00
G01N 33/53

4241841, 514 2, 435 4, 435 723

Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.

7511117, Mar 31, 2009

Nov 20, 2007

11/943034

Ananda Chakrabarty - Villa Park IL, US
Tapas Das Gupta - River Forest IL, US
Tohru Yamada - Oak Park IL, US
Anita Chaudhari - Clifton Park NY, US
Arsenio Fialho - Lisbon, PT
Chang Soo Hong - Chicago IL, US

The Board of Trustees of the University of Illinois - Urbana IL

C07K 5/00

530300

The present invention relates to cupredoxin, specifically azurin, and/or cytochrome cand their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.

7556810, Jul 7, 2009

Jul 19, 2006

11/488693

Rajeshwari R. Mehta - Orland Park IL, US
Brad N. Taylor - Chicago IL, US
Tohru Yamada - Oak Park IL, US
Craig W. Beattie - Chicago IL, US
Tapas K. Das Gupta - River Forest IL, US
Ananda M. Chakrabarty - Villa Park IL, US

The Board of Trustees of the University of Ilinois - Urbana IL

A61K 39/00
A61K 39/38
A61K 39/02

4241851, 424 91, 424 92, 4241841, 4241901, 4241921, 4242341, 4242501, 4242531, 4242601, 530300, 530350, 536 231, 536 237

The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development.

7691383, Apr 6, 2010

Oct 6, 2005

11/244105

Ananda Chakrabarty - Villa Park IL, US
Tapas Das Gupta - River Forest IL, US
Tohru Yamada - Oak Park IL, US
Arsenio Fialho - Lisbon, PT

The Board of Trustees of the University of Illinois - Urbana IL

A61K 39/00
A61K 49/00
A61K 39/10

4241851, 424 91, 424 92, 4241841, 4241901, 4241921, 4242341, 4242501, 4242531, 4242601, 530300, 530350, 536 231, 536 237

The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.

7740857, Jun 22, 2010

Mar 3, 2008

12/041411

Ananda Chakrabarty - Villa Park IL, US
Tapas Das Gupta - River Forest IL, US
Tohru Yamada - Oak Park IL, US
Anita Chaudhari - Clifton Park NY, US
Arsenio Fialho - Lisbon, PT
Chang Soo Hong - Chicago IL, US

The Board of Trustees of the University of Illinois - Urbana IL

A61K 39/00
A61K 38/44
C12P 21/04
C07K 14/445

4241851, 424 944, 435 697, 4352581, 530300, 514 12

The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.