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Timothy H Bayburt

from Fort Wayne, IN
Age ~58
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Also known as:
Timothy Hasan Bayburt, Tim H Bayburt, Timothy H Gurevich, Rita Blake Smith, Rita Hall, Rita Blake, Rita Smith
Phone and address:
3414 Buckeye Run, Fort Wayne, IN 46814
Related to:
Tulay E Bayburt, 61Michael D HallEsmeralda L Bedolla, 36Carolyn Y Smith, 66Michelle SmithCarolyn Smith, 77
Connected to:
Henry S Baybutt, 65Philip M Baychuk, 63Johanna C Baycroft, 51Cara Baycura, 42John D Baycura, 68Christopher L Bayda, 41Betsy D Baydala, 40Terence F Baydala, 65Irina Baydaline, 52Alexander Baydar, 36

Timothy Bayburt Phones & Addresses

  • 3414 Buckeye Run, Fort Wayne, IN 46814
  • 2512 Southmoor Dr, Champaign, IL 61821 (217) 398-0961
  • Urbana, IL
  • Seattle, WA
  • Ann Arbor, MI
  • Mount Juliet, TN
  • Hermitage, TN

Publications

Us Patents

Membrane Scaffold Proteins

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US Patent:
7083958, Aug 1, 2006
Filed:
Jun 18, 2003
Appl. No.:
10/465789
Inventors:
Stephen G. Sligar - Urbana IL, US
Timothy H. Bayburt - Urbana IL, US
Mary A. Schuler - Urbana IL, US
Natanya R Civjan - Urbana IL, US
Yelena V. Grinkova - Urbana IL, US
Ilia G. Denisov - Urbana IL, US
Assignee:
The Board of Trustees of the University of Illinois - Urbana IL
International Classification:
C12N 9/00
C07K 14/435
US Classification:
435183, 530350
Abstract:
Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. The membrane scaffold proteins (MSP) of the present invention assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their native structure and function; they are improved over liposomes and detergent micelles. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles, which are robust in terms of integrity and maintenance of biological activity of incorporated proteins, facilitate pharmaceutical and biological research, structure/function correlation, structure determination, bioseparation, and drug discovery.

Membrane Scaffold Proteins And Tethered Membrane Proteins

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US Patent:
7575763, Aug 18, 2009
Filed:
May 23, 2006
Appl. No.:
11/439458
Inventors:
Stephen G. Sligar - Urbana IL, US
Timothy H. Bayburt - Champaign IL, US
Assignee:
The Board of Trustees of the University of Illinois - Urbana IL
International Classification:
A61K 9/14
C07K 14/00
C07K 14/435
US Classification:
424499, 530350, 530402
Abstract:
Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their native structure and function; they are improved over liposomes and detergent micelles. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles facilitate pharmaceutical and biological research, structure/function correlation, structure determination, bioseparation, and drug discovery.

Membrane Scaffold Proteins

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US Patent:
7592008, Sep 22, 2009
Filed:
Jan 11, 2005
Appl. No.:
11/033489
Inventors:
Stephen G. Sligar - Urbana IL, US
Timothy H. Bayburt - Urbana IL, US
Mary A. Schuler - Urbana IL, US
Natanya R. Civjan - Urbana IL, US
Ylena V. Grinkova - Urbana IL, US
Ilia G. Denisov - Urbana IL, US
Stephen James Grimme - Urbana IL, US
Assignee:
The Board of Trustees of the University of Illinois, a body corporate and politic of the State of Illinois - Urbana IL
International Classification:
A61K 39/00
A61K 38/00
A61K 39/12
A61K 39/02
A61K 39/002
US Classification:
4241841, 4241851, 4242041, 4242341, 4242651, 4242741, 4242771, 424400
Abstract:
The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and function; they are improved over liposomes and detergent micelles, in terms of stability and preservation of biological activity and native conformation. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles, which are robust in terms of integrity and maintenance of biological activity of incorporated proteins, facilitate pharmaceutical and biological research, structure/function correlations, structure determinations, bioseparations, and drug discovery.

Membrane Scaffold Proteins And Embedded Membrane Proteins

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US Patent:
7662410, Feb 16, 2010
Filed:
May 23, 2006
Appl. No.:
11/439466
Inventors:
Stephen G. Sligar - Urbana IL, US
Timothy H. Bayburt - Champaign IL, US
Assignee:
The Board of Trustees of the University of Illinois - Urbana IL
International Classification:
A61K 9/14
C07K 14/00
C07K 14/435
US Classification:
424499, 530350, 530402
Abstract:
Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their native structure and function; they are improved over liposomes and detergent micelles. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles facilitate pharmaceutical and biological research, structure/function correlation, structure determination, bioseparation, and drug discovery.

Membrane Scaffold Proteins

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US Patent:
7691414, Apr 6, 2010
Filed:
Nov 2, 2004
Appl. No.:
10/979506
Inventors:
Stephen G. Sligar - Urbana IL, US
Timothy H. Bayburt - Urbana IL, US
Assignee:
The Board of Trustees of the University of Illinois - Urbana IL
International Classification:
A61K 9/14
C07K 14/00
C07K 14/435
US Classification:
424499, 530350, 530402
Abstract:
Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their native structure and function; they are improved over liposomes and detergent micelles. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles facilitate pharmaceutical and biological research, structure/function correlation, structure determination, bioseparation, and drug discovery.

Membrane Scaffold Proteins

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US Patent:
20060057662, Mar 16, 2006
Filed:
Nov 20, 2001
Appl. No.:
09/990087
Inventors:
Stephen Sligar - Urbana IL, US
Timothy Bayburt - Urbana IL, US
International Classification:
C07K 14/72
C12P 21/06
US Classification:
435069100, 435320100, 435325000, 530350000, 435317100
Abstract:
Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their native structure and function; they are improved over liposomes and detergent micelles. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles facilitate pharmaceutical and biological research, structure/function correlation, structure determination, bioseparation, and drug discovery.

Membrane Scaffold Proteins

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US Patent:
20090257950, Oct 15, 2009
Filed:
Oct 10, 2007
Appl. No.:
11/870217
Inventors:
Stephen G. Sligar - Urbana IL, US
Timothy H. Bayburt - Urbana IL, US
Mary A. Schuler - Urbana IL, US
Natanya R. Civjan - Urbana IL, US
Yelena V. Grinkova - Urbana IL, US
Ilia G. Denisov - Urbana IL, US
Stephen James Grimme - Urbana IL, US
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - Urbana IL
International Classification:
A61K 51/08
A61K 9/14
A61K 47/42
A61K 38/16
A61K 38/02
A61K 31/7052
A61K 31/70
A61K 31/7048
A61K 31/497
A61K 39/395
A61K 49/00
A61P 43/00
US Classification:
424 169, 424499, 514773, 514 12, 514 2, 514 44 R, 514 23, 514 31, 51425405, 4241781, 424 91
Abstract:
The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and function; they are improved over liposomes and detergent micelles, both in terms of stability and preservation of biological activity and native conformation. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles, which are robust in terms of integrity and maintenance of biological activity of incorporated proteins, facilitate pharmaceutical and biological research, structure/function correlations, structure determinations, bioseparations, and drug discovery.

Biomimetic Chemical Sensors Using Nanoelectronic Readout Of Olfactory Receptors

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US Patent:
20170299602, Oct 19, 2017
Filed:
Nov 16, 2016
Appl. No.:
15/353118
Inventors:
- Philadelphia PA, US
- Urbana IL, US
Bohdana Discher - Philadelphia PA, US
Stephen G Sligar - Urbana IL, US
Timothy H Bayburt - Champaign IL, US
International Classification:
G01N 33/68
G01N 33/543
G01N 33/543
G01N 33/543
G06F 19/28
G01N 33/68
Abstract:
The present invention provides biomimetic sensor devices that utilize proteins—such G-protein coupled receptors—and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and methods of using the devices to assay samples.
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Timothy H Bayburt from Fort Wayne, IN, age ~58 Get Report