Inventors:
Mark A. Gallop - Los Altos CA, US
Xuedong Dai - San Jose CA, US
Randall A. Scheuerman - Santa Clara CA, US
Stephen P. Raillard - Mountain View CA, US
Suresh K. Manthati - Cupertino CA, US
Fenmei Yao - Mountain View CA, US
Thu Phan - Fremont CA, US
Maria Ludwikow - Cupertino CA, US
Ge Peng - Mountain View CA, US
Seema Bhat - Santa Clara CA, US
Assignee:
XenoPort, Inc. - Santa Clara CA
International Classification:
C07D 207/46
Abstract:
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.