Thorsten E Fisher

6380249, Apr 30, 2002

Jun 1, 1999

09/323417

Steven D. Young - Lansdale PA
Melissa Egbertson - Ambler PA
Linda S. Payne - Lansdale PA
John S. Wai - Harleysville PA
Thorsten E. Fisher - Hatfield PA
Mark W. Embrey - North Wales PA
Lekhanh Tran - Norristown PA
Linghang Zhuang - Conshohocken PA
Joseph P. Vacca - Telford PA
H. Marie Langford - Lansdale PA
Jeffrey Melamed - Warminster PA
Juan C. Jaen - Burlingame CA
David L. Clark - Albany CA
Julio C. Medina - Belmont CA

Merck Co., Inc. - Rahway NJ
Tularik Inc. - S. San Francisco CA

A61K 31215

514530, 514531, 514538, 514539, 514541, 560 19, 560 48, 560 51, 560 53, 562426, 562433, 562441, 562451, 562452, 562457, 562459, 562462, 562463

Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

6921759, Jul 26, 2005

Oct 10, 2001

09/973853

Neville J. Anthony - Hatfield PA, US
Robert P. Gomez - Perkasie PA, US
Steven D. Young - Lansdale PA, US
Melissa Egbertson - Ambler PA, US
John S. Wai - Harleysville PA, US
Linghang Zhuang - Chalfont PA, US
Mark Embrey - North Wales PA, US
Jeffrey Y. Melamed - Doylestown PA, US
H. Marie Langford - Lansdale NJ, US
James P. Guare - Quakertown PA, US
Thorsten E. Fisher - Hatfield PA, US
Samson M. Jolly - Quakertown PA, US
Michelle S. Kuo - Gwynedd Valley PA, US
Debra S. Perlow - East Greenville PA, US
Jennifer J. Bennett - East Norriton PA, US
Timothy W. Funk - Ephrata PA, US

Merck & Co., Inc. - Rahway NJ

A61P031/00
A61K031/4375
C07D471/02

51421103, 51421108, 514218, 5142222, 5142225, 5142282, 5142345, 514249, 51425304, 514274, 514275, 514300, 514303, 540488, 540489, 540492, 540545, 544 3, 544 8, 544 586, 544127, 544310, 544331, 544349, 544362, 546118, 546 9, 546123

Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

7435735, Oct 14, 2008

Oct 18, 2004

10/576328

John S. Wai - Harleysville PA, US
Thorsten E. Fisher - Hatfield PA, US
Linghang Zhuang - Chalfont PA, US
Donnette D. Staas - Harleysville PA, US
Terry A. Lyle - Lederach PA, US
Boyoung Kim - Lansdale PA, US
Mark W. Embrey - North Wales PA, US
Catherine M. Wiscount - Allentown PA, US
Lekhanh O. Tran - Norristown PA, US
Melissa Egbertson - Ambler PA, US
Kelly L. Savage - Schwenksville PA, US

Merck & Co., Inc. - Rahway NJ

A01N 43/58
A01N 43/60
A61K 31/50
A61K 31/495
C07D 471/00
C07D 487/00
C07D 241/36

514250, 544345

Hydroxy-substituted pyridopyrrolopyrazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I): (I) wherein a, b, A, B, R, R, R, R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

7517532, Apr 14, 2009

Sep 10, 2003

10/526275

John S. Wai - Harleysville PA, US
Boyoung Kim - Lansdale PA, US
Thorsten E. Fisher - Hatfield PA, US
Peter D. Williams - Harleysville PA, US
H. Marie Langford - Lansdale PA, US

Merck & Co., Inc. - Rahway NJ

A61K 39/21
C07D 241/00
C07D 241/02
C07D 241/36
C07D 471/00
C07D 487/00
C07D 491/00
C07D 495/00
C07D 497/00

4242081, 544336, 544349, 544350

8,9-Dihydroxydihydropyridopyrazine-1,6-diones and 8,9-dihydroxypyridopyrazine-1,6-diones are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the pyridopyrazinediones are of Formula (I): (I), wherein R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are described.

7538112, May 26, 2009

May 3, 2005

11/579772

John S. Wai - Harleysville PA, US
Joseph P. Vacca - Telford PA, US
Linghang Zhuang - Chalfont PA, US
Boyoung Kim - Lansdale PA, US
Terry A. Lyle - Lederach PA, US
Catherine M. Wiscount - Allentown PA, US
Melissa S. Egbertson - Ambler PA, US
Lou Anne Neilson - Sellersville PA, US
Mark Embrey - Harleysville PA, US
Thorsten E. Fisher - Hatfield PA, US
Donnette D. Staas - Harleysville PA, US

Merck & Co., Inc. - Rahway NJ

C07D 487/14
A61K 31/5025
A61K 31/4985

514250, 544234

Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R, R, R, R, R, Rand Rare defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

7619086, Nov 17, 2009

Mar 4, 2005

10/591914

Matthew M. Morrissette - Radnor PA, US
Peter D. Williams - Harleysville PA, US
John S. Wai - Harleysville PA, US
Thorsten E. Fisher - Hatfield PA, US
Terry A. Lyle - Lederach PA, US

Merck & Co., Inc. - Rahway NJ

C07D 221/18
C07D 221/22
A01N 43/40
A61K 31/435

546 26, 514277

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication:.

8513234, Aug 20, 2013

Oct 2, 2009

12/572341

Richard C. A. Isaacs - Harleysville PA, US
Wayne J. Thompson - Lansdale PA, US
Peter D. Williams - Harleysville PA, US
Dai-Shi Su - Dresher PA, US
Shankar Venkatraman - Lansdale PA, US
Mark W. Embrey - Harleysville PA, US
Thorsten E. Fisher - Hatfield PA, US
John S. Wai - Harleysville PA, US
David C. Dubost - Collegeville PA, US
Richard G. Ball - Edison NJ, US
Eric J. Choi - Westfield NJ, US
Tao Pei - Morganville NJ, US
Sarah L. Trice - Glenside PA, US
Neil Campbell - Cherry Hill NJ, US
Matthew Maddess - Boston MA, US
Peter E. Maligres - Fanwood NJ, US
Michael Shevlin - Plainfield NJ, US
Zhiguo Jake Song - Edison NJ, US
Dietrich P. Steinhuebel - Boston MA, US
Neil A. Strotman - Monmouth Junction NJ, US
Jingjun Yin - Green Brook NJ, US

Merck Sharp & Dohme Corp. - Rahway NJ

C07D 487/12

51421402, 540579

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication:.

20030229079, Dec 11, 2003

Jun 6, 2003

10/260029

Linda Payne - Lansdale PA, US
Lekhanh Tran - Norristown PA, US
Linghang Zhuang - Chalfont PA, US
Steven Young - Lansdale PA, US
Melissa Egbertson - Ambler PA, US
John Wai - Harleysville PA, US
Mark Embrey - North Wales PA, US
Thorsten Fisher - Hatfield PA, US
James Guare - Quakertown PA, US
H. Marie Langford - Lansdale PA, US
Jeffrey Melamed - Warminster PA, US
David Clark - Albany CA, US

A61K031/542
A61K031/538
A61K031/522
A61K031/498
A61K031/506
A61K031/497
A61K031/4439

514/222200, 514/230500, 514/256000, 514/255050, 514/263220, 514/341000, 544/047000, 544/105000, 544/277000, 544/331000, 544/405000, 544/350000, 546/268100, 514/249000

Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.