US Patent:
20130022583, Jan 24, 2013
Inventors:
Marius Wernig - Stanford CA, US
Thomas C. Sudhof - Stanford CA, US
Thomas Vierbuchen - Stanford CA, US
Austin Ostermeier - West Plains MO, US
Zhiping Pang - Stanford CA, US
International Classification:
C12N 5/0797
C12N 5/079
C12Q 1/04
G01N 33/566
A61P 37/00
C12Q 1/68
A61K 35/30
A61P 25/00
A61P 25/28
A61P 25/18
C12N 5/0793
G01N 33/573
US Classification:
424 937, 435377, 435354, 435368, 435325, 435 34, 435 721, 435 74, 435 71, 435 612
Abstract:
Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the CNS. Also provided are methods, compositions and kits for screening candidate agents for activity in converting cells into neuronal cells, astrocytes, oligodendrocytes, and progenitor cells thereof.