Thomas J Sowin

6355490, Mar 12, 2002

Sep 4, 1997

08/923206

Jill Edie Hochlowski - Green Oaks IL, 60048
Thomas J. Sowin - Wadsworth IL, 60083
Daniel W. Norbeck - Crystal Lake IL, 60012
Anne-Laure Marie Grillot - Cambridge IL, 60093
Rolf E. Swenson - Grayslake IL, 60030

G01N 33543

436518, 436527, 436528, 436531, 436 56, 530333, 530334, 530335, 558303, 558411, 558415, 558416, 558414, 558435, 558441

The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.

6667404, Dec 23, 2003

Feb 7, 2003

10/360325

Dale J. Kempf - Libertyville IL
Daniel W. Norbeck - Crystal Lake IL
Hing Leung Sham - Gurnee IL
Chen Zhao - Gurnee IL
Thomas J. Sowin - Grayslake IL
Daniel S. Reno - Kenosha WI
Anthony R. Haight - Park City IL

Abbott Laboratories - Abbott Park IL

C07D27724

548204, 548205, 548214, 548236, 514372, 514374

A retroviral protease inhibiting compound of the formula: is disclosed.

7163939, Jan 16, 2007

Nov 3, 2004

10/980740

Nan-Horng Lin - Vernon Hills IL, US
Gaoquan Li - Park City IL, US
Magdalena K. Przytulinska - Chicago IL, US
Thomas J. Sowin - Wadsworth IL, US
Gerard M. Sullivan - Lake Villa IL, US
Zhi-Fu Tao - Gurnee IL, US
Yunsong Tong - Libertyville IL, US
Le Wang - Vernon Hills IL, US

Abbott Laboratories - Abbott Park IL

C07D 513/08
A61K 31/529

5142315, 514250, 540456

Compounds having the formula.

7320986, Jan 22, 2008

Mar 3, 2004

10/792564

Yunsong Tong - Grayslake IL, US
Akiyo K. Claiborne - Mundelein IL, US
Gaoquan Li - Park City IL, US
Nan-Horng Lin - Vernon Hills IL, US
Hing L. Sham - Vernon Hills IL, US
Thomas J. Sowin - Wadsworth IL, US
Zhi-Fu Tao - Gurnee IL, US

Abbott Labortories - Abbott Park IL

A61K 31/4745
A61K 31/4162
C07D 487/14

514292, 514406, 546 82, 5483595

Compounds having the formula (I).

7456169, Nov 25, 2008

Aug 23, 2006

11/466638

Lisa A. Hasvold - Grayslake IL, US
Laura Hexamer - Gurnee IL, US
Gaoquan Li - Madison WI, US
Nan-Horng Lin - Vernon Hills IL, US
Hing Sham - South San Francisco CA, US
Thomas J. Sowin - Wadsworth IL, US
Gerard M. Sullivan - Labe Villa IL, US
Le Wang - Mundelein IL, US
Ping Xia - St. Louis MO, US

Abbott Laboratories Inc. - Abbott Park IL

C07D 413/00
A61K 31/5513

514220, 540495

Compounds having the formula.

20050096324, May 5, 2005

Nov 5, 2003

10/702140

Zhi-Fu Tao - Gurnee IL, US
Nan-Horng Lin - Vernon Hills IL, US
Le Wang - Vernon Hills IL, US
Thomas Sowin - Wadsworth IL, US

A61K031/498
C07D491/14

514250000, 540456000, 540460000

Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

55413285, Jul 30, 1996

Apr 3, 1995

8/415385

Timothy L. Stuk - Lindenhurst IL
Michael S. Allen - Silver Lake WI
Anthony R. Haight - Mundelein IL
Francis A. Kerdesky - Grayslake IL
Denton C. Langridge - Wildwood IL
M. Robert Leanna - Grayslake IL
Linda M. Lijewski - Milwaukee WI
Laura Melcher - Deerfield IL
Howard E. Morton - Gurnee IL
Daniel W. Norbeck - Crystal Lake IL
Daniel S. Reno - Kenosha WI
Timothy A. Robbins - Gurnee IL
Hing L. Sham - Mundelein IL
Thomas J. Sowin - Grayslake IL
Chen Zhao - Gurnee IL
David Scarpetti - Baltimore MD

Abbott Laboratories - Abbott Park IL

C07C25178
C07C22114
C07C20944

546 99

A substantially pure compound of formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl; or R. sub. 6 and R. sub. 7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R. sub. f, R. sub. g, R. sub. h and R. sub. l are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; and R. sub. g is hydrogen, loweralkyl or benzyl; or an acid addition salt thereof.

56250924, Apr 29, 1997

Apr 10, 1995

8/419168

Timothy L. Stuk - Lindenhurst IL
Michael S. Allen - Silver Lake WI
Anthony R. Haight - Mundelein IL
Francis A. J. Kerdesky - Grayslake IL
Denton C. Langridge - Wildwood IL
M. Robert Leanna - Grayslake IL
Linda M. Lijewski - Milwaukee WI
Laura Melcher - Deerfield IL
Howard E. Morton - Gurnee IL
Daniel W. Norbeck - Crystal Lake IL
Daniel S. Reno - Kenosha WI
Timothy A. Robbins - Gurnee IL
David Scarpetti - Evanston IL
Hing L. Sham - Mundelein IL
Thomas J. Sowin - Grayslake IL
Chen Zhao - Gurnee IL

Abbott Laboratories - Abbott Park IL

C07C26100
C07C23300
C07D20904

560 24

Intermediates and processes are disclosed which are useful for the preparation of a substantially pure compound of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are each hydrogen or R. sub. 6 and R. sub. 7 are independently selected from ##STR2## wherein R. sub. a and R. sub. b are independently selected from hydrogen, loweralkyl and phenyl and R. sub. c, R. sub. d and R. sub. e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R. sub. 6 is as defined above and R. sub. 7 is R. sub. 7a OC(O)-- wherein R. sub. 7a is loweralkyl or benzyl; or R. sub. 6 and R. sub.