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Thomas W Patapoff

from Captain Cook, HI
Age ~68
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Also known as:
Thomas William Patapoff, Ma Therese Patapoff, Ma T Patapoff, Tom W Patapoff, Maria T Patapoff, Therese Patapoff Ma
Phone and address:
82-5970 Napoopoo Rd, Captain Cook, HI 96704
(650) 369-8887
Related to:
Michele CrenshawRobert Thornton, 96Robert Shoemaker, 85Jacob Thornton, 45
Connected to:
Teri R Patapoff, 49Mark R Patarini, 56Camilo A Patarroyo, 37Bernard J Patashnik, 85Jeffrey M Patashna, 50Patsy W Patat, 65Emmanuel Patatoukos, 41Jill E Patava, 57Christine J Patberg, 56Gary L Patburg, 80

Thomas Patapoff Phones & Addresses

  • 82-5970 Napoopoo Rd, Captain Cook, HI 96704 (650) 369-8887
  • 2408 Dekoven Ave, Belmont, CA 94002
  • 418 Winding Way, San Carlos, CA 94070 (650) 595-5887
  • 2604 Graceland Ave, San Carlos, CA 94070
  • San Mateo, CA
  • Gulf Breeze, FL

Education

Degree: Graduate or professional degree

Publications

Us Patents

Compaction Assay For Assessment Of Respiratory Disease Therapy

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US Patent:
20020034727, Mar 21, 2002
Filed:
Jan 25, 2001
Appl. No.:
09/771078
Inventors:
Ann Daugherty - Palo Alto CA, US
Randy Mrsny - Redwood City CA, US
Thomas Patapoff - Belmont CA, US
Assignee:
Genentech, Inc.
International Classification:
C12Q001/00
US Classification:
435/004000
Abstract:
A compaction assay measuring the viscoelasticity of sputum samples of patients subject to respiratory disease is provided. This assay is useful in determining the therapeutic efficacy of DNase, antibiotic and other respiratory disease treatments in improving lung function.

Compaction Assay For Assessment Of Respiratory Disease Therapy

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US Patent:
20030165810, Sep 4, 2003
Filed:
Jun 4, 2002
Appl. No.:
10/162951
Inventors:
Ann Daugherty - Palo Alto CA, US
Randy Mrsny - Redwood City CA, US
Thomas Patapoff - Belmont CA, US
Assignee:
Genentech, Inc.
International Classification:
C12Q001/00
US Classification:
435/004000
Abstract:
A compaction assay measuring the viscoelasticity of sputum samples of patients subject to respiratory disease is provided. This assay is useful in determining the therapeutic efficacy of DNase, antibiotic and other respiratory disease treatments in improving lung function.

Compaction Assay For Assessment Of Respiratory Disease Therapy

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US Patent:
20050164334, Jul 28, 2005
Filed:
Jan 10, 2005
Appl. No.:
11/033358
Inventors:
Ann Daugherty - Palo Alto CA, US
Randy Mrsny - Redwood City CA, US
Thomas Patapoff - Belmont CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12Q001/04
G01N033/86
US Classification:
435034000, 436070000
Abstract:
A compaction assay measuring the viscoelasticity of sputum samples of patients subject to respiratory disease is provided. This assay is useful in determining the therapeutic efficacy of DNase, antibiotic and other respiratory disease treatments in improving lung function.

Antibody Selection Apparatus And Methods

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US Patent:
20210065843, Mar 4, 2021
Filed:
Nov 12, 2020
Appl. No.:
17/095970
Inventors:
- South San Francisco CA, US
Trevor E. Swartz - San Carlos CA, US
Thomas W. Patapoff - San Carlos CA, US
International Classification:
G16B 15/00
G16B 35/00
G16C 20/60
C07K 16/00
G01N 33/531
Abstract:
Apparatus, systems, computer-readable media, articles of manufacture and methods for selecting an antibody. Apparatus, systems, computer-readable media, articles of manufacture and methods for producing the selected antibody. The selecting may include determining one or more physiochemical characteristics of the antibody. The determining may be based on antibody structural parameters.

Antibody Formulations

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US Patent:
20200179516, Jun 11, 2020
Filed:
Dec 20, 2019
Appl. No.:
16/723864
Inventors:
- South San Francisco CA, US
Isidro E. ZARRAGA - South San Francisco CA, US
Jonathan ZARZAR - South San Francisco CA, US
Thomas PATAPOFF - South San Francisco CA, US
International Classification:
A61K 47/26
A61K 39/395
A61K 9/08
C07K 16/22
C07K 16/28
Abstract:
The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.

Elucidation Of Ion Exchange Chromatography Input Optimization

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US Patent:
20190310234, Oct 10, 2019
Filed:
Mar 12, 2019
Appl. No.:
16/351372
Inventors:
- South San Francisco CA, US
Thomas Patapoff - South San Francisco CA, US
Yajun Wang - South San Francisco CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
G01N 30/86
G01N 33/68
G01N 30/96
C07K 1/18
C07K 1/16
G01N 30/34
B01D 15/38
B01D 15/36
Abstract:
The present invention provides methods for determining chromatography separation conditions; for example, separation of a polypeptide and its charge variants. The invention also provides methods to determine a buffer condition for chromatography separation conditions. The invention also provides a robust method to analyze multiple polypeptide products.

Antibody Formulations

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US Patent:
20180280514, Oct 4, 2018
Filed:
Oct 18, 2017
Appl. No.:
15/787265
Inventors:
- South San Francisco CA, US
Isidro E. ZARRAGA - South San Francisco CA, US
Jonathan ZARZAR - South San Francisco CA, US
Thomas PATAPOFF - South San Francisco CA, US
Christine WURTH - Loerrach, DE
International Classification:
A61K 47/26
C07K 16/28
C07K 16/22
A61K 39/395
A61K 9/08
Abstract:
The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a pH in the range of about 5.5 to about 7.0. The invention also provides methods for making such formulations and methods of using such formulations.

Ionic Strength-Mediated Ph Gradient Ion Exchange Chromatography

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US Patent:
20180120273, May 3, 2018
Filed:
Sep 29, 2017
Appl. No.:
15/721389
Inventors:
- South San Francisco CA, US
George Tony MORENO - South San Francisco CA, US
Boyan ZHANG - South San Francisco CA, US
Liangyi ZHANG - South San Francisco CA, US
Dell FARNAN - South San Francisco CA, US
Thomas PATAPOFF - South San Francisco CA, US
International Classification:
G01N 30/96
G01N 33/68
C07K 1/18
Abstract:
The present invention provides methods for analyzing compositions of polypeptides such as antibodies by ionic strength-mediated pH gradient ion exchange chromatography. In some aspects, the methods use a combination of pH gradients and ionic strength gradients to separate the polypeptide from charge variants of the polypeptide. In some aspects, the methods use a stable ionic strength to optimize the pH gradient separation window to separate the polypeptide from charge variants. Such methods are useful for analyzing polypeptide, e.g. antibodies, with a pI greater than 9 or a pI less than 7. In some aspects, the invention provides a multiproduct method for the analysis of polypeptides of varying pI's.
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Thomas W Patapoff from Captain Cook, HI, age ~68 Get Report