Inventors:
Thomas A. Horbett - Seattle WA
Buddy D. Ratner - Seattle WA
Joseph A. Chinn - Seattle WA
Yasmeen Haque - Pasadena CA
Assignee:
The Board of Regents for the University of Washington - Seattle WA
International Classification:
A61F 206
Abstract:
A method for enhancing bio-material capability for use as a supporting surface for cell culture is disclosed. The method requires exposure of the bio-material to a plasma polymerizable polymer gas, which includes oxygen-containing organic molecules. The material surfaces are then subjected to an RF plasma gas discharge in the presence of the gas, causing a deposition on the exposed material surfaces of a conformal overcoating of the polymer on the material. The deposition enhances fibronectin adsorption and hence cell attachment, spreading and cell growth. Preferred polymerizable gases are acetone, methanol, and ethylene oxide.
