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Thomas J Blacklock

from Clark, NJ
Age ~72
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Also known as:
Thomas Dr Blacklock, Thomasj Blacklock
Phone and address:
493 Valley Rd, Clark, NJ 07066
(732) 381-4538
Related to:
Joanne W Dorolek, 79Gregory Thomas Dorolek, 50Roland C BlacklockAlan T Blacklock, 36Mary V Blacklock, 65Karen E Blacklock, 30Anna W BlocklockClair Blacklock
Connected to:
Brittany S Blacklock, 37Cindy A Blacklock, 67Eileen N Blacklock, 93Jane C Blacklock, 53Jeff Blacklock, 63Karla S Blacklock, 64Kevin L Blacklock, 61Lisa C Blacklock, 52Lyndsey A Blacklock, 61Matthew W Blacklock, 51

Thomas Blacklock Phones & Addresses

  • 493 Valley Rd, Clark, NJ 07066 (732) 381-4538
  • Rahway, NJ
  • 29 Shepard Ave, Akron, NY 14001 (716) 542-2336
  • 493 Valley Rd, Clark, NJ 07066

Work

Position: Professional/Technical

Education

Degree: Graduate or professional degree

Emails

t***[email protected]

Resumes

Resumes

Thomas Blacklock Photo 1

Thomas Blacklock

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Location:
United States

Publications

Us Patents

Organic Compounds

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US Patent:
20090156585, Jun 18, 2009
Filed:
Nov 8, 2006
Appl. No.:
11/722360
Inventors:
Lili Feng - Pine Brook NJ, US
Sven Erik Godtfredsen - Chatham NJ, US
Bin Hu - Green Brook NJ, US
Yugang Liu - Bridgewater NJ, US
Piotr Karpinski - Lincoln Park NJ, US
Paul Allen Sutton - Parsippany NJ, US
Mahavir Prashad - Montville NJ, US
Michael J. Girgis - Montville NJ, US
Thomas J. Blacklock - Clark NJ, US
International Classification:
A61K 31/41
C07D 257/04
C07D 403/10
A61K 31/4178
A61P 9/10
A61P 25/00
A61K 31/549
A61K 31/4422
A61P 9/00
A61K 31/216
C07D 409/06
C07C 229/34
US Classification:
5142235, 548253, 5483054, 5483151, 560 39, 514381, 514394, 514397, 514382, 514533, 514356
Abstract:
A specific combination, linked pro-drug or a compound of an angiotensin receptor antagonist and a NEPi are used in the treatment of hypertension.

(S)-Alkyl 3-(Thien-2-Ylthio)Butyrate And Analogs And Synthesis Thereof

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US Patent:
49688146, Nov 6, 1990
Filed:
Apr 18, 1990
Appl. No.:
7/510806
Inventors:
Thomas J. Blacklock - Clark NJ
Edward J. J. Grabowski - Westfield NJ
Paul Sohar - Warren NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D33332
US Classification:
549 66
Abstract:
(S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs are intermediates in the synthesis of the chiral (S,S)-5,6-dihydro-4-ethylamino-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfon amide-7,7-dioxide and analogs thereof, topically effective carbonic anhydrase inhibitors useful in the treatment of ocular hypertension and glaucoma.

Chiral Catalysts For Reduction Of Ketones And Process For Their Preparation

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US Patent:
52645851, Nov 23, 1993
Filed:
Oct 26, 1992
Appl. No.:
7/966658
Inventors:
Thomas J. Blacklock - Clark NJ
Todd K. Jones - Edison NJ
David J. Mathre - Skillman NJ
Lyndon C. Xavier - Edison NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07F 502
C07B 4900
C07B 4100
C07D21122
US Classification:
548405
Abstract:
The chiral catalyst of general structure 1, or its enantiomer ##STR1## is prepared by treating the corresponding N-carboxy anhydride of structure 2 ##STR2## with an aryl metal, especially a phenyl metal such as an aryl magnesium halide, aryl lithium, aryl zinc or aryl cesium, to form a 1,1-diaryl- methanol of structure 3 ##STR3## followed by treatment with a compound of structure, 4 ##STR4## The catalyst, wherein R is aromatic, is novel and in some cases superior to the catalyst wherein R is alkyl or aralkyl in directing the chirality of diborane, borane-dimethyl sulfide or borane-tetrahydrofuran reductions of ketones to secondary alcohols.

Chiral Boron Catalysts For Reduction Of Ketones And Process For Their Preparation

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US Patent:
51891778, Feb 23, 1993
Filed:
Jul 15, 1991
Appl. No.:
7/730316
Inventors:
Thomas J. Blacklock - Clark NJ
Todd K. Jones - Salan Beach CA
David J. Mathre - Skillman NJ
Lyndon C. Xavier - Edison NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07F 502
US Classification:
548405
Abstract:
The chiral catalyst of general structure 1, or its enantiomer ##STR1## is prepared by treating the corresponding N-carboxy anhydride of structure 2 ##STR2## with an aryl metal, especially a phenyl metal such as an aryl magnesium halide, aryl lithium, aryl zinc or aryl cesium, to form a 1,1-diaryl- methanol of structure 3 ##STR3## followed by treatment with a compound of structure, 4 ##STR4## The catalyst, wherein R is aromatic, is novel and in some cases superior to the catalyst wherein R is alkyl or aralkyl in directing the chirality of diborane, borane-dimethyl sulfide or borane-tetrahydrofuran reductions of ketones to secondary alcohols.

Process For Racemizing An Enantiomer Of 5,6-Dihydro-4-Alkylamino-4H-Thieno(Or Furo) [2,3-B]-Thiopyran-2-Sulfonamide-7,7-Dioxide

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US Patent:
50119427, Apr 30, 1991
Filed:
Feb 5, 1990
Appl. No.:
7/474868
Inventors:
Thomas J. Blacklock - Clark NJ
Edward J. J. Grabowski - Westfield NJ
Paul Sohar - Warren NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D49506
US Classification:
549 23
Abstract:
Compounds classified as 5,6-dihydro-4-alkylamino-4H-thieno (or furo) [2,3-b]thiopyran-2-sulfonamide-7,7-dioxide are carbonic anhydrase inhibitors useful in the treatment of ocular hypertension, and most of the carbonic anhydrase inhibitory activity resides in only one of the enantiomers. The undesired enantiomer is utilized by racemization by thermolysis of an N-acyl derivative in a basic environment followed by removal of the acyl group. The racemate may then be resolved into the enantiomers.

Process For Preparing Polypeptides

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US Patent:
45100837, Apr 9, 1985
Filed:
May 31, 1983
Appl. No.:
6/499743
Inventors:
Thomas J. Blacklock - Clark NJ
Richard F. Shuman - Westfield NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07C10352
US Classification:
2601125R
Abstract:
A process for producing polypeptides is disclosed wherein potassium, rubidium, or cesium serves as the counterion for both the carbonate buffer system and the amino acid or peptide salts employed.

Enantiospecific Synthesis Of S-(+)-5,6-Dihydro-4-(R-Amino)-4H-Thieno(2,3-B)Thiopyran-2-Sulfonamide-7, 7-Dioxide

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US Patent:
51571293, Oct 20, 1992
Filed:
Apr 18, 1990
Appl. No.:
7/510804
Inventors:
Thomas J. Blacklock - Clark NJ
Todd K. Jones - Edison NJ
Edward J. J. Grabowski - Westfield NJ
David J. Mathre - Edison NJ
Julie J. Mohan - Edison NJ
Paul Sohar - Warren NJ
F. Edward Roberts - Princeton NJ
Lyndon C. Xavier - Edison NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D49504
US Classification:
549 23
Abstract:
5,6-Dihydro-4-(R-amino)-4H-thieno[2,3-b]-thiopyran-2-sulfonamide-7,7-dioxid e is a potent carbonic anhydrase inhibitor useful in the treatment of ocular hypertension and glaucoma. The S-(+)-enantiomer of that compound, the more active enantiomer, is prepared by a process involving an intermediate step of an enantioselective reduction of a carbonyl group employing an oxazaborolidine chiral catalyst.

Enantioselective Synthesis Of 5,6-Dihydro-(S)-4-(Ethylamino)-(S)-6-Methyl-4H-Thieno?2,3-B!Thiopyran-2- Sulfonamide 7,7-Dioxide

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US Patent:
56889682, Nov 18, 1997
Filed:
Jan 6, 1995
Appl. No.:
8/369557
Inventors:
Thomas J. Blacklock - Clark NJ
David J. Mathre - Skillman NJ
Paul Sohar - Warren NJ
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D49504
US Classification:
549 23
Abstract:
A key step in the synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno�2,3-b!thiopyran-2-su lfonamide 7,7-dioxide (dorzolamide) and related compounds is a Ritter reaction with an unexpected tendency to proceed with retention of chirality.

Wikipedia

Thomas Blacklock

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Thomas Blacklock (10 November, 1721 7 July, 1791) was a Scottish poet. He was born near Annan, Dumfries and Galloway, of humble parentage, and lost his sight

Isbn (Books And Publications)

An Essay on Universal Etymology, 1756

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Author

Thomas Blacklock

ISBN #

0854174834

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Thomas J Blacklock from Clark, NJ, age ~72 Get Report