Thomas J Bardos

20030216334, Nov 20, 2003

Feb 10, 2003

10/182224

Janos Aradi - Debrecen, HU
Thomas Bardos - Williamsville NY, US
Joseph Dunn - Williamsville NY, US

A61K048/00
C07H021/04

514/044000, 536/023100

The present invention relates to a novel method for inhibiting the growth, elaboration and/or replication of HIV in human patients and to the prevention and treatment of human acquired immunodeficiency syndrome (AIDS) and other diseases caused by retroviral infection. In preferred aspects, the present invention provides a method for the use of a novel class of oligodeoxynucleotides consisting of 4-thio-2′-deoxyuridylate units for the prevention and treatment of both wild-type and drug-resistant Human Immunodeficiency Virus 1 (HIV), the causative pathogen of AIDS.

51927640, Mar 9, 1993

May 30, 1991

7/707536

Yung-Chi Cheng - Woodbridge CT
Tai-Shun Lin - North Haven CT
Thomas J. Bardos - Snyder NY

Research Foundation of State of N.Y. - Albany NY
Yale University - New Haven CT

A61K 31495
C07D24102

514252

This invention relates to nucleoside and acyclo analogs containing 5- or 6-substituted 2-pyrazinone-4-N-oxide. These compounds are useful for treating various conditions including viral infections, cancer, fungal infections, bacterial infections, microbial infections and related disease states. This invention also relates to pharmaceutical formulations containing these compounds. In addition, this invention relates to methods of treating the above-described conditions in animals and in particular, humans.

46173986, Oct 14, 1986

Apr 12, 1982

6/367338

Thomas J. Bardos - Snyder NY
Michael E. Perlman - Amherst NY

The Research Foundation of State University of New York - Albany NY

C07D40302
C07D40314
A61K 31395

548112

Novel phosphoaziridines of the formula: ##STR1## wherein Z is oxygen or sulfur, R. sub. 1 is independently at each occurrence H or --CH. sub. 3, R. sub. 2 is independently at each occurrence --CH. sub. 3 or nitrophenyl R. sub. 5 ; R. sub. 3 is --NHR. sub. 4, --OR. sub. 4, --SR. sub. 4 or ##STR2## where R. sub. 4 is a radical containing up to 30 atoms including at least one amine, ester, ether, alkyl, substituted alkyl, hydrogen, phenyl, substituted phenyl, carbamate, heterocyclic ring or R. sub. 5 group; provided that, when R. sub. 4 contains and R. sub. 5 group, R. sub. 4 has an alkyl group between the phosphorous and the R. sub. 5 group; and R. sub. 5 is a radical containing and electron affinic group comprising a quinone, or a heterocyclic or phenyl ring directly connected to a radical selected from the group consisting of nitro, nitroso, sulfinyl, sulfoxine, and N-oxide; provided that the compound contains at least one R. sub. 5 radical and provided that when R. sub. 1 is H, the R. sub.

48959375, Jan 23, 1990

Oct 27, 1988

7/263183

Thomas J. Bardos - Snyder NY
Yung-Chi Cheng - Chapel Hill NC
Alan C. Schroeder - Silver Springs MD

The Research Foundation of State University of New York - Albany NY

C07H 19067

536 23

The nuceoside 1-(2-Deoxy-. beta. -D-ribofuranosyl)-5-(iodo)-2-pyrimidinone possesses a high level of antiviral activity and a low level of toxicity to the host cell making it an especially effective therapeutic agent for HSV-2.

45445010, Oct 1, 1985

Apr 12, 1983

6/484213

Thomas J. Bardos - Snyder NY
Michael E. Perlman - Bronxville NY
Joan E. MacDiarmid - Amherst NY

The Research Foundation of State University of New York - Albany NY

C07D20306
A61K 31395

260239EP

Novel bis(2,2-dimethyl-1-aziridinyl)phosphinic amide antineoplastic agents are disclosed of the formula: ##STR1## wherein R and R' are each, independently, hydrogen, alkyl, substituted alkyl, phenyl and substituted phenyl and, Z is oxygen or sulfur.

44683847, Aug 28, 1984

Jan 5, 1982

6/337297

Thomas J. Bardos - Snyder NY
Yung-Chi Cheng - Chapel Hill NC
Alan C. Schroeder - Buffalo NY

The Research Foundation of State University of New York - Albany NY

A61K 3170
A61K 39245

424180

A method for inhibiting the replication of a DNA virus which induces formation of thymidine kinase enzyme, by exposing the virus to an effective concentration of a compound of the formula: ##STR1## wherein R. sub. 1 is a radical selected from the group consisting of halogen, --SCH. sub. 3, --OH, alkoxy, cyano, methylamino, carboxy, formyl, nitro and unsubstituted or halosubstituted hydrocarbon groups of 1 through 3 carbon atoms; R. sub. 2 is hydrogen; halogen or hydroxy; and R. sub. 3 is hydroxy, --OP(O)(OH). sub. 2, amino, or --OOR. sub. 4 where R. sub. 4 is lower alkyl of 1 through 6 carbon atoms.

48867900, Dec 12, 1989

Mar 2, 1988

7/163283

Thomas J. Bardos - Snyder NY
Michael E. Perlman - Durham NC
Joan E. MacDiarmid - Amherst NY

The Research Foundation of State University of New York - Albany NY

A61K 31675
C07D20306

514 83

A method of inhibiting the replication of tumor cells is disclosed wherein Novel bis (2,2-dimethyl-1-aziridinyl)phosphinic amide antineoplastic agents of the formula: ##STR1## wherein X is R and R' are each, independently, hydrogen, alkyl, substituted alkyl, phenyl and substituted phenyl, Y is alkyl or substituted alkyl of 1-10 carbon atoms and, Z is oxygen or sulfur is administered to tumor cells.

48821470, Nov 21, 1989

Dec 16, 1987

7/133524

Thomas J. Bardos - Snyder NY
Steven J. Kasper - Rochester NY
Robert G. Hughes - Kenmore NY

The Research Foundation of State University of New York - Albany NY

A61K 3900
A61K 4502

424 854

Polyribonucleotide analogs which are partially substituted by the introduction of mercapto groups and fluorine at the 5-position of some of their cytosine and uracil bases possess effective in vivo antitumor activity. Double stranded complexes formed from such polynucleotides are especially active as interferon inducers.