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Thimma R Rawalpally

from Florence, SC
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Also known as:
Reka Rawalpally, Rekha R Rawalpally
Phone and address:
3313 Trenton St, Florence, SC 29501
(843) 317-9937
Connected to:
Mark A Rawalt, 61Lillian M Rawan, 79Ariane M Rawanduzy, 34Ajay V Rawani, 32Ali S Rawas, 39Naser K Rawashdeh, 51Anisha Rawat, 52Anita N Rawat, 50Aprajita Rawat, 41Bhim S Rawat, 58

Thimma Rawalpally Phones & Addresses

  • 3313 Trenton St, Florence, SC 29501 (843) 317-9937
  • Woodland Park, NJ
  • North Chelmsford, MA
  • 61 Trevino Rd, Flanders, NJ 07836
  • 3313 Trenton St, Florence, SC 29501 (864) 441-4141

Work

Company: Roche 2014 to Apr 2016 Position: Drug substance technical leader

Education

Degree: Associates School / High School: Drexel University 1987 to 1991 Specialities: Organic Chemistry

Ranks

Certificate: Pmp and Regulatory Affairs Certificate (2015)

Industries

Pharmaceuticals

Resumes

Resumes

Thimma Rawalpally Photo 1

Regulatory Program Director

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Location:
South San Francisco, CA
Industry:
Pharmaceuticals
Work:
Roche 2014 - Apr 2016
Drug Substance Technical Leader
Genentech 2014 - Apr 2016
Regulatory Program Director
Roche Aug 2011 - 2013
Principle Manufacturing Technical Specialist
Roche 2005 - 2010
Senior Principal Scientist
Roche 1997 - 2005
Principal Scientist
Education:
Drexel University 1987 - 1991
Associates, Organic Chemistry
Certifications:
Pmp and Regulatory Affairs Certificate (2015)

Business Records

Name / Title
Company / Classification
Phones & Addresses
Thimma Rawalpally
Manager
Carolina Roche Inc
Mfg Pharmaceutical Preparations
6173 E Old Marion Hwy, Florence, SC 29506
6175 E Old Marion Hwy, Florence, SC 29506
(843) 629-4300

Publications

Us Patents

Particles Having An Attached Stable Free Radical, Polymerized Modified Particles, And Methods Of Making The Same

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US Patent:
6337358, Jan 8, 2002
Filed:
Oct 29, 1998
Appl. No.:
09/181926
Inventors:
Robert S. Whitehouse - Lexington MA
Wayne Devonport - Tewksbury MA
Russell L. Warley - Hudson NH
Thimma Rawalpally - Florence SC
Hairuo Tu - Burlington MA
Assignee:
Cabot Corporation - Boston MA
International Classification:
C08K 900
US Classification:
523200, 523215, 523216, 25218314
Abstract:
A modified particle is disclosed wherein a particle has an attached group having the formula: wherein A represents an aromatic group or an alkyl group; R represents a bond, an arylene group, an alkylene group, wherein R is an alkyl or alkylene group or an aryl or arylene group; R and R , which can be the same or different, represent hydrogen, an alkyl group, an aryl group, âOR , âNHR , âNR R , or âSR , wherein R , which is the same or different, represents an alkyl group or an aryl group; and SFR represents a stable free radical. Also disclosed is a modified particle or aggregate having attached a group having the formula: wherein CoupA represents a Si-containing group, a Ti-containing group, a Cr-containing group or a Zr-containing group; R and R , which can be the same or different, represent hydrogen, an alkyl group, an aryl group, âOR , âNHR , âNR R , or âSR , wherein R represents an alkyl group or an aryl group; SFR represents a stable free radical; and n is an integer of from to. A modified particle having an attached âSFR or âXâSFR is additionally disclosed. Also, modified particles with attached polymers are also disclosed as well as methods of making the modified particles.

Methods Of Making A Particle Having An Attached Stable Free Radical

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US Patent:
6368239, Apr 9, 2002
Filed:
Jun 3, 1998
Appl. No.:
09/089363
Inventors:
Wayne Devonport - Tewksbury MA
Robert S. Whitehouse - Lexington MA
Russell L. Warley - Erie PA
Thimma R. Rawalpally - Florence SC
Hairuo Tu - Burlington MA
Assignee:
Cabot Corporation - Boston MA
International Classification:
C01D 300
US Classification:
4734492, 4234499, 524496, 106 316, 106 3175
Abstract:
A modified particle is disclosed wherein a particle has an attached group having the formula: wherein Ar represents an aromatic group; R represents a bond, an arylene group, an alkylene group, wherein R is an alkyl or alkylene group or an aryl or arylene group; R and R , which can be the same or different, represent hydrogen, an alkyl group, an aryl group, âOR , âNHR , âNR R , or âSR , wherein R , which is the same or different, represents an alkyl group or an aryl group; and SFR represents a stable free radical. Also disclosed is a modified particle or aggregate having attached a group having the formula: wherein CoupA represents a Si-containing group, a Ti-containing group, or a Zr-containing group; R and R , which can be the same or different, represent hydrogen, an alkyl group, an aryl group, âOR , âNHR , âNR R , or âSR , wherein R represents an alkyl group or an aryl group; SFR represents a stable free radical; and n is an integer of from 1 to 3. A modified particle having an attached âSFR or âXâSFR is additionally disclosed. Also, modified particles with attached polymers are also disclosed as well as methods of making the modified particles.

Methods Of Making A Particle Having An Attached Stable Free Radical

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US Patent:
6551393, Apr 22, 2003
Filed:
Feb 1, 2002
Appl. No.:
10/061948
Inventors:
Wayne Devonport - Tewksbury MA
Robert S. Whitehouse - Lexington MA
Russell L. Warley - Erie PA
Thimma R. Rawalpally - Florence SC
Hairuo Tu - Burlington MA
Assignee:
Cabot Corporation - Boston MA
International Classification:
C09D 1100
US Classification:
106 316, 106 3175, 106472, 106473, 4234492, 4234499, 524495, 524496, 524513, 524514, 524528, 524521, 524523, 525165, 525175, 525192
Abstract:
A modified particle is disclosed wherein a particle has an attached group having the formula: wherein Ar represents an aromatic group; R represents a bond, an arylene group, an alkylene group, wherein R is an alkyl or alkylene group or an aryl or arylene group; R and R , which can be the same or different, represent hydrogen, an alkyl group, an aryl group, âOR , âNHR , âNR R , or âSR , wherein R , which is the same or different, represents an alkyl group or an aryl group; and SFR represents a stable free radical. Also disclosed is a modified particle or aggregate having attached a group having the formula: wherein CoupA represents a Si-containing group, a Ti-containing group, or a Zr-containing group; R and R , which can be the same or different, represent hydrogen, an alkyl group, an aryl group, âOR , âNHR , âNR R , or âSR , wherein R represents an alkyl group or an aryl group; SFR represents a stable free radical; and n is an integer of from 1 to 3. A modified particle having an attached âSFR or âXâSFR is additionally disclosed. Also, modified particles with attached polymers are also disclosed as well as methods of making the modified particles.

Methods For Stabilizing Lithiated Halogen-Substituted Aromatic Compounds

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US Patent:
7619123, Nov 17, 2009
Filed:
Oct 24, 2008
Appl. No.:
12/257419
Inventors:
Yaohui Ji - Florence SC, US
Thimma Rawalpally - Florence SC, US
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
C07C 45/00
US Classification:
568426, 568437
Abstract:
The present invention provides novel methods for stabilizing lithiated halogen-substituted aromatic compounds. In particular, the method is useful for the preparation of 2-methoxy-5,6-difluorobenzaldehyde, an important intermediate for the preparation of [4-amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6methoxyphenyl)methanone, a potent and selective inhibitor of CDK4/Cyclin D1, CDK2/Cyclin E and CDK1/Cyclin B. The method is also useful for stabilizing other lithiated halogen-substituted aromatic compounds and is particularly useful for scale up reactions where the exothermic nature of the reaction can lead to reaction runway.

Process For The Preparation Of 3-Amino-Pentan-1,5-Diol

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US Patent:
7635784, Dec 22, 2009
Filed:
Jun 9, 2008
Appl. No.:
12/135240
Inventors:
Thomas Cleary - Florence SC, US
Yaohui Ji - Florence SC, US
Gary R. Lee - Belmont CA, US
Thimma Rawalpally - Florence SC, US
Keshab Sarma - Sunnyvale CA, US
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
Roche Palo Alto LLC - Palo Alto CA
International Classification:
C07C 269/00
US Classification:
560157, 560160
Abstract:
The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.

Diazonium-Free Method To Make An Indazole Intermediate In The Synthesis Of Bicyclic 5-(Trifluormethoxy)-1H-3-Indazolecarboxylic Acid Amides

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US Patent:
8232412, Jul 31, 2012
Filed:
Oct 9, 2009
Appl. No.:
12/576259
Inventors:
Thomas Cleary - Florence SC, US
Yaohui Ji - Shanghai, CN
Thimma Rawalpally - Florence SC, US
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
C07D 231/56
C07D 231/54
US Classification:
5483625, 5483611
Abstract:
The present invention provides novel methods for preparing 5-(trifluoromethoxy)-1H-3-indazolecarboxylic acid (3), which is a useful precursor for the preparation of bicyclic-5-trifluoromethoxy-1H-indazole-3-carboxylic acid amides of Formula (1). Compounds of Formula (1) are active as agonists and partial agonists of the nicotinic α-7 receptor and are being studied for their use in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders. The present methods are useful for preparing compound (3) on scale up levels.

Diazonium-Free Method To Make An Indazole Intermediate In The Synthesis Of Bicyclic 5-(Trifluormethoxy)-1H-3-Indazolecarboxylic Acid Amides

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US Patent:
8354536, Jan 15, 2013
Filed:
Jun 21, 2012
Appl. No.:
13/528894
Inventors:
Thomas Cleary - Florence SC, US
Yaohui Ji - Shanghai, CN
Thimma Rawalpally - Florence SC, US
Assignee:
Hoffman-La Roche Inc. - Nutley NJ
International Classification:
C07D 453/02
C07D 241/38
US Classification:
546135, 544349, 540555
Abstract:
The present invention provides novel methods for preparing 5-(trifluoromethoxy)-1H-3-indazolecarboxylic acid (3), which is a useful precursor for the preparation of bicyclic-5-trifluoromethoxy-1H-indazole-3-carboxylic acid amides of Formula (1). Compounds of Formula (1) are active as agonists and partial agonists of the nicotinic α-7 receptor and are being studied for their use in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders. The present methods are useful for preparing compound (3) on scale up levels.

Particle Having An Attached Stable Free Radical And Methods Of Making The Same

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US Patent:
6068688, May 30, 2000
Filed:
Nov 12, 1997
Appl. No.:
8/968299
Inventors:
Robert S. Whitehouse - Lexington MA
Russell L. Warley - Erie PA
Thimma R. Rawalpally - Florence SC
Hairuo Tu - Burlington MA
Assignee:
Cabot Corporation - Boston MA
International Classification:
C09D 1100
C08K 904
C09C 162
C09C 164
C09C 100
US Classification:
106 3165
Abstract:
A modified particle is disclosed wherein a particle has an attached group having the formula: ##STR1## wherein Ar represents an aromatic group; R. sup. 1 represents a bond, an arylene group, an alkylene ##STR2## wherein R. sup. 4 is an alkyl or alkylene group or an aryl or arylene group; R. sup. 2 and R. sup. 3, which can be the same or different, represent hydrogen, an alkyl group, an aryl group, --OR. sup. 5, --NHR. sup. 5, --NR. sup. 5 R. sup. 5, or --SR. sup. 5, wherein R. sup. 5, which is the same or different, represents an alkyl group or an aryl group; and SFR represents a stable free radical. Also disclosed is a modified particle or aggregate having attached a group having the formula: ##STR3## wherein CoupA represents a Si-containing group, a Ti-containing group, or a Zr-containing group; R. sup. 8 and R. sup. 9, which can be the same or different, represent hydrogen, an alkyl group, an aryl group, --OR. sup. 10, --NHR. sup. 10, --NR. sup. 10 R. sup.
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Thimma R Rawalpally from Florence, SC Get Report