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Thijs Kaper

from Half Moon Bay, CA
Age ~53
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Connected to:
Neil C Kapera, 65Raymond E Kapera, 64Lenette Kaperak, 54Margaret E Kaperick, 78Judith R Kapernaros, 68Martha P Kaperonis, 93Sandra C Kaperonis, 82Brandon J Kapes, 52Courtney E Kapes, 39Esther H Kapes, 81

Thijs Kaper Phones & Addresses

  • 670 Myrtle St, Half Moon Bay, CA 94019
  • East Palo Alto, CA
  • Redwood City, CA
  • San Carlos, CA

Publications

Us Patents

Trp/His Exchange And Kynurenin Induced Trp Transport

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US Patent:
8071744, Dec 6, 2011
Filed:
Apr 28, 2011
Appl. No.:
13/096643
Inventors:
Thijs Kaper - Palo Alto CA, US
Michael Platten - Dossenheim, DE
Lawrence Steinman - Stanford CA, US
Wolf Frommer - Stanford CA, US
Assignee:
Carnegie Institution of Washington - Washington DC
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C12N 15/62
US Classification:
536 234
Abstract:
The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.

Compositions And Methods Comprising Cellulase Variants With Reduced Affinity To Non-Cellulosic Materials

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US Patent:
8236542, Aug 7, 2012
Filed:
Jun 3, 2009
Appl. No.:
12/477887
Inventors:
Thijs Kaper - Palo Alto CA, US
Bradley R Kelemen - Menlo Park CA, US
Amy D. Liu - Sunnyvale CA, US
Assignee:
Danisco US Inc. - Palo Alto CA
International Classification:
C12N 9/14
C12P 19/00
C12P 7/06
US Classification:
435195, 435 72, 435161
Abstract:
The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.

Trp/His Exchange And Kynurenine Induced Trp Transport

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US Patent:
20080227140, Sep 18, 2008
Filed:
Feb 29, 2008
Appl. No.:
12/040524
Inventors:
Thijs Kaper - Palo Alto CA, US
Michael Platten - Dossenheim, DE
Lawrence Steinman - Stanford CA, US
Wolf Frommer - Stanford CA, US
International Classification:
C12Q 1/02
C12N 5/06
US Classification:
435 29, 435375
Abstract:
The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.

Multimetric Biosensors And Methods Of Using Same

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US Patent:
20080311047, Dec 18, 2008
Filed:
Nov 16, 2006
Appl. No.:
12/091859
Inventors:
Thijs Kaper - Palo Alto CA, US
Wolf B. Frommer - Stanford CA, US
International Classification:
C12N 15/11
C12N 15/12
C12N 15/13
C12N 15/52
C12N 1/21
C12N 1/19
C12N 5/10
A01K 67/027
A01H 5/00
G01N 33/53
A61K 49/00
C12N 15/63
US Classification:
424 96, 536 231, 536 232, 536 235, 536 2353, 43525233, 4352542, 435410, 800 13, 435 72, 800298, 4353201
Abstract:
Multimeric tryptophan biosensors are disclosed, which comprise tryptophan-binding domains conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon tryptophan binding. Such biosensors are useful for real time monitoring of tryptophan metabolism in living cells.

Cellulase Variants With Improved Expression, Activity And Stability, And Use Thereof

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US Patent:
20120135500, May 31, 2012
Filed:
Jun 3, 2010
Appl. No.:
13/321928
Inventors:
Wolfgang Aehle - Zwingenberg, DE
Richard R. Bott - Burlingame CA, US
Benjamin Bower - Newark CA, US
Jonathan Caspi - sunnyvale CA, US
David A. Estell - San Francisco CA, US
Frits Goedegebuur - vlaardingen, NL
Ronaldus W.J. Hommes - Haarlem, NL
Thijs Kaper - Half Moon Bay CA, US
Bradley Kelemen - Menlo Park CA, US
Slavko Kralj - Oegstgeest, NL
Johan Van Lieshout - Utrecht, NL
Igor Nikolaev - Noordwijk, NL
Sander Van Stigt Thans - Zevenbergen, NL
Louise Wallace - Palo Alto CA, US
Gudrun Vogtentanz - Sunnyvale CA, US
Mats Sandgren - Uppsala, SE
Assignee:
Danisco US Inc. - Palo Alto CA
International Classification:
C12N 9/42
US Classification:
435209
Abstract:
The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof.

Compositions And Methods Comprising Cellulase Variants With Reduced Affinity To Non-Cellulosic Materials

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US Patent:
20120276595, Nov 1, 2012
Filed:
Jul 6, 2012
Appl. No.:
13/543627
Inventors:
Thijs Kaper - Half Moon Bay CA, US
Bradley R. Kelemen - Menlo Park CA, US
Amy D. Liu - Sunnyvale CA, US
Assignee:
DANISCO US INC. - Palo Alto CA
International Classification:
C12N 9/42
C12P 7/14
C12P 19/14
US Classification:
435 99, 435209, 435162
Abstract:
The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having reduced binding to non-cellulosic materials. Also described are nucleic acids encoding the cellulase, compositions comprising said cellulase, methods of identifying cellulose variants and methods of using the compositions.

Beta-Glucosidase I Variants With Improved Properties

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US Patent:
20130143301, Jun 6, 2013
Filed:
Nov 19, 2010
Appl. No.:
13/510902
Inventors:
Richard R. Bott - Burlingame CA, US
Thijs Kaper - Half Moon Bay CA, US
Bradley Kelemen - Menlo Park CA, US
Frits Goedegebuur - Vlaardingen, NL
Ronaldus Hommes - Haarlem, NL
Slavko Kralj - Oestgeest, NL
Paulien Kruithof - Zoetmeer, NL
Igor Nikolaev - Noordwijk, NL
Assignee:
Danisco US Inc. - Palo Alto CA
International Classification:
C12N 9/24
US Classification:
435209, 536 232, 4353201, 43525411, 4352546, 4352545, 4352543, 4352547, 4352542, 43525421
Abstract:
The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.

Filamentous Fungal Host Strains And Dna Constructs, And Methods Of Use Thereof

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US Patent:
20130149742, Jun 13, 2013
Filed:
Jun 3, 2011
Appl. No.:
13/701479
Inventors:
Benjamin S. Bower - Newark CA, US
Thijs Kaper - Half Moon Bay CA, US
Bradley R. Kelemen - Menlo Park CA, US
Assignee:
Danisco US Inc. - Palo Alto CA
International Classification:
C12N 15/80
US Classification:
435 691, 43525411, 4352546, 4352545, 4352543, 4352547, 4352544
Abstract:
The present disclosure relates to filamentous fungal host strains and recombinant DNA constructs for creation and use thereof. The filamentous fungal host strains are particularly useful for achieving reliable expression of recombinant enzymes and variants.
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Thijs Kaper from Half Moon Bay, CA, age ~53 Get Report