Inventors:
Theo A. Hymas - Valley Center CA
Cynthia L. Becker - Worthington MN
Assignee:
HMV Associates, Inc. - Alpine UT
International Classification:
A61K 3900
US Classification:
4242011, 4241841, 4242021, 4242641, 435243
Abstract:
The present invention provides a bacterin comprising at least two virulent isolates of differing biotypes, in an amount sufficient to immunize a calf or cow against infection by , an adjuvant, and a pharmaceutically acceptable carrier. Further provided is a method of producing the bacterin of the present invention. Finally, the present invention also provides a method of immunizing a calf or cow against infection, especially infection associated with BRD, comprising administering to the calf or cow a dose of a bacterin made according to the present invention in an amount effective to elicit a protective response in the animal, as evidenced by a decrease in the mortality and morbidity associated with natural infection.