Inventors:
Sylvie Laquerre - Walnut Creek CA
Terry Hermiston - Corte Madera CA
Assignee:
Onyx Pharmaceuticals, Inc. - Richmond CA
International Classification:
A01N 6300
US Classification:
424 932, 4353201, 435325, 435 9141, 435 691
Abstract:
The present invention relates to pharmaceutical compositions, kits, and methods of use thereof, comprising, a mutant human herpes simplex-type 1 virus, which is cytopathic to susceptible hyperproliferative cells, such as neoplastic cells. Preferably, the virus does not produce a fully functionally active wild-type ICP0 polypeptide coded for the IE gene 1.