US Patent:
20120269841, Oct 25, 2012
Inventors:
Maninder K. Sidhu - New City NY, US
Annaliesa Sybil Anderson - Upper Saddle River NJ, US
Robert G. K. Donald - South Orange NJ, US
Kathrin Ute Jansen - Allendale NJ, US
Narender K. Kalyan - Ridgewood NJ, US
Terri L. Mininni - New Windsor NY, US
Justin Keith Moran - Valley Cottage NY, US
Mark E. Ruppen - Garnerville NY, US
Michael James Flint - Decatur GA, US
International Classification:
A61K 39/08
A61P 37/02
C07K 14/33
Abstract:
In one aspect, the invention relates to an immunogenic composition that includes a mutant toxin A and/or a mutant toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.