Inventors:
Samuel Hassenbusch - Houston TX, US
Mary Johansen - Sugar Land TX, US
Tamara Gradert - Bastrop TX, US
William Satterfield - Elgin TX, US
Larry Trissel - Houston TX, US
International Classification:
A61K031/551
Abstract:
The invention provides a preservative-free midazolam hydrochloride formulation that is less toxic, and more effective than present opioid therapies for alleviation of pain. Additionally, by an intrathecal infusion system for continuous administration of preservative-free midazolam hydrochloride the present invention circumvents breakthrough pain episodes often encountered with other means of opioid administration. The present invention further provides a novel method of treating pain that is of either non-neuropathic or neuropathic origin. Overall that present invention provides a method of treating cancer pain in patients by continuous intrathecal infusion of preservative-free midazolam hydrochloride.