Inventors:
Erkki Ruoslahti - Rancho Santa Fe CA, US
Kimmo Porkka - Helsinki, FI
Sven Christian - San Diego CA, US
Assignee:
Sanford-Burnham Medical Research Institute - La Jolla CA
International Classification:
C07K 5/00
C07K 14/00
G01N 33/574
Abstract:
The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds the receptor bound by peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID NO: 9). Methods of directing a conjugate of the invention to tumor blood vessels and tumor cells and of using a conjugate to treat cancer also are provided.