Susan Rachel Cooper

20140295508, Oct 2, 2014

Mar 28, 2014

14/229388

Yasuo Yoshikuni - Albany CA, US
Susan R. Cooper - Berkeley CA, US
Adam J. Wargacki - Berkeley CA, US
Leo E. Manzer - Wilmington DE, US
James F. White - Richland WA, US
Lou Kapicak - South Charleston WV, US
Dennis J. Miller - Okemos MI, US
Lars Peereboom - Haslett MI, US

C07D 307/68

435137, 549485, 549484

Provided are methods of producing 2,5-furandicarboxylic acid (FDCA) from renewable sources such as seaweed, alginate, oligoalginate, pectin, oligopectin, polygalacturonate, galacturonate, and/or oligogalacturonate. The sugars in the renewable sources can be converted into one or more intermediates such as 4-deoxy-L-erythro-5-hexoseulose uronate (DEHU), 4-deoxy-L-threo-5-hexosulose uronate (DTHU), 5-hydroxymethyl furfural (HMF), 2,5-dihydroxymethyl furan (DHMF), and 5-formyl-2-furancarboxylic acid (FFA), which can be converted into FDCA by dehydration and cyclization to produce 5-formyl-2-furancarboxylic acid (FFA), followed by oxidation to produce FDCA. DEHU or DTHU may also be converted into FDCA by oxidation to produce 2,3-dihydroxy-5-oxohexanedioic acid (DOHA), which then undergoes dehydration and cyclization to produce FDCA.