Steven J Goldstein

8417322, Apr 9, 2013

Jun 29, 2004

10/879797

Michael D. Morris - Ann Arbor MI, US
Steven A. Goldstein - Ann Arbor MI, US
Barbara R. McCreadie - Ann Arbor MI, US
Tso-Ching Chen - Ann Arbor MI, US

Regents of the University of Michigan - Ann Arbor MI

A61B 5/00

600477

In a method for diagnosing or helping to diagnose a bone tissue condition of a patient, a portion of bone tissue of the patient is irradiated using a light source. The bone tissue may be irradiated in vivo through the skin or via an incision, for example. Alternatively, a biopsy of the bone tissue may be irradiated. Then, spectral content information for light scattered, reflected, or transmitted by the bone tissue is determined, and is used, at least in part, to determine whether the patient has a bone tissue condition.

20020193338, Dec 19, 2002

Jun 20, 2002

10/177680

Steven Goldstein - Ann Arbor MI, US
Jeffrey Bonadio - Ann Arbor MI, US

A61K048/00

514/044000, 424/423000

The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.

20050119587, Jun 2, 2005

Sep 17, 2004

10/944518

Blake Roessler - Ann Arbor MI, US
Michael Morris - Ann Arbor MI, US
Steven Goldstein - Ann Arbor MI, US
Abigail Smukler - Ann Arbor MI, US
Nicole Crane - Ypsilanti MI, US
Barbara McCreadie - Ann Arbor MI, US
Tso-Ching Chen - Whitmore Lake MI, US

UNIVERSITY OF MICHIGAN - Ann Arbor MI

A61B010/00

600562000

In a method for evaluating a connective tissue condition of a patient, an indicator of the supporting tissue condition may be generated. A portion of connective tissue of the patient is irradiated using a light source. The connective tissue may be irradiated in vivo through the skin or via an incision, for example. Alternatively, a biopsy of the connective tissue may be irradiated. Then, spectral content information for light scattered, reflected, or transmitted by the connective tissue is determined. The spectral content information is used, at least in part, to generate the indicator. The indicator may assist a physician in diagnosing or ruling out the connective tissue condition, determining a risk of developing a disease, monitoring the progression of a disease, monitoring a response to treatment, etc.

20060035854, Feb 16, 2006

Feb 28, 2005

11/068735

Steven Goldstein - Ann Arbor MI, US
Robert Levy - Ann Arbor MI, US
Vinod Labhasetwar - Ann Arbor MI, US
Jeffrey Bonadio - Ann Arbor MI, US

A61K 48/00
A61K 9/14
A61L 9/04

514044000, 424045000, 424046000

The present invention provides compositions and methods for coating medical devices with pharmaceutical agents and devices coated with the compositions. The coated devices provide controlled or sustained release of pharmaceutical agents for the treatment of wounds or disease.

20090198184, Aug 6, 2009

Feb 5, 2009

12/322716

David C. Martin - Ann Arobor MI, US
Antonio Peramo - Ann Arbor MI, US
Steven A. Goldstein - Ann Arbor MI, US

A61M 5/00
A61M 1/00
A61M 25/14
A61B 17/60
A61B 17/58
A61B 17/70
A61F 2/82
A61F 2/18
A61F 2/60
A61F 2/54

604151, 60428804, 604523, 604264, 606 54, 606 53, 606246, 623 115, 623 10, 623 27, 623 57

A percutaneous biomedical device comprising a body having a lumen extending longitudinally at least partially through the body, an implantable interface region disposed on the body, the implantable interface region having a plurality of radially extending conduits through the body, each of the conduits are in fluid communication with the lumen and in fluid communication with an exit port. The exit ports extrude a skin-interface composition between the subject's skin and the percutaneous biomedical device. Methods for implanting a percutaneous biomedical device includes implanting a percutaneous biomedical device percutaneously in a subject and aligning the exit ports of the implantable interface region between the epidermis and the hypodermis skin layers of the subject.

20100189792, Jul 29, 2010

Jan 26, 2009

12/360056

Steven A. Goldstein - Ann Arbor MI, US
Jeffrey Bonadio - Ann Arbor MI, US

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

A61K 31/7088
A61K 9/14
A61P 17/02

424484, 514 44 R

The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.

20120100107, Apr 26, 2012

Jan 10, 2012

13/347451

Steven A. Goldstein - Ann Arbor MI, US
Jeffrey Bonadio - Ann Arbor MI, US

The Regents of the University of Michigan - Ann Arbor MI

A61K 31/7088
A61P 17/02

424 932, 514 44 R

The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.

46593314, Apr 21, 1987

Nov 28, 1983

6/555812

Larry S. Matthews - Ann Arbor MI
Steven A. Goldstein - Ann Arbor MI

Regents of University of Michigan - Ann Arbor MI

A61F 238

623 20

An improved prosthesis interface surface is incorporated on any implantable component where stable long lasting bone fixation is needed. The surface achieves immediate stabilization of the prosthetic component and promotes bony tissue ingrowth by either making the surface of a porous metal or ceramic or coating the surface of the interface surface with a porous metal or ceramic. In the preferred embodiment, the surface includes a large number of conical protrusions which are specifically designed to resist shear and torsional disruptive forces while accommodating the compression loads that occur during motion of a joint prosthesis. By utilizing a series of conical protrusions, the surface contact area of the interface surface is much greater than interface surfaces now in use and this large surface contact area improves stability and provides a large area for secure bony ingrowth fixation. The improved prosthesis interface surface of the present invention may be used in hip, knee, ankle and shoulder joint replacement components as well as in any other implant component which is to be secured in trabecular bone. Additionally, the interface surface may be used to implant artificial dentures and for bony insertions of artificial ligaments and tendons.