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Steven E Cwirla

from Menlo Park, CA
Age ~63
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Also known as:
Steven Eric Cwirla, Steven G Cwirla, Steven E Owirla, Steve E Cwirla, Steven E Wirla
Phone and address:
111 Hedge Rd, Menlo Park, CA 94025
Related to:
Timothy J Evans, 24Erwin ShakinDouglas Evans, 38Cheryl Perz, 62Donna Murray, 60Phyllis Shakin, 89
Connected to:
Gary J Cwyk, 68Connie S Cwynar, 61Daniel M Cwynar, 72Paul J Cwynar, 46Todd Cyaira, 37Andreas H Cybalski, 64Eugene P Cybart, 31Neil Cybart, 39Sharon A Cybart, 65Tadeusz A Cybin, 75

Steven Cwirla Phones & Addresses

  • 111 Hedge Rd, Menlo Park, CA 94025
  • 765 San Antonio Rd, Palo Alto, CA 94303
  • 4131 Crestline St, Chicago, IL 60652
  • Hickory Hills, IL

Interests

job inquiries, expertise requests, busin...

Industries

Biotechnology

Resumes

Resumes

Steven Cwirla Photo 1

Senior Scientist At Xenoport

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Location:
San Francisco Bay Area
Industry:
Biotechnology
Experience:
XenoPort (Public Company; 51-200 employees; XNPT; Pharmaceuticals industry): Senior Scientist,  (-) Affymax, Inc (Biotechnology industry): Sr. Scientist,  (1989-2000) 

Publications

Us Patents

Peptides And Compounds That Bind To A Thrombopoietin Receptor

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US Patent:
6465430, Oct 15, 2002
Filed:
Apr 13, 2000
Appl. No.:
09/549090
Inventors:
William J. Dower - Menlo Park CA
Ronald W. Barrett - Saratoga CA
Steven E. Cwirla - Menlo Park CA
David J. Duffin - East Palo Alto CA
Christian M. Gates - Morgan Hill CA
Sherril S. Haselden - Santa Cruz CA
Larry C. Mattheakis - Cupertino CA
Peter J. Schatz - Mountain View CA
Christopher R. Wagstrom - Los Altos CA
Nicholas C. Wrighton - Palo Alto CA
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 3800
US Classification:
514 13, 514 14, 514 15, 4241851
Abstract:
Receptors are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

Labeled Compounds That Bind To A Thrombopoietin Receptor

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US Patent:
6506362, Jan 14, 2003
Filed:
Apr 10, 2001
Appl. No.:
09/832230
Inventors:
William J. Dower - Menlo Park CA
Ronald W. Barrett - Saratoga CA
Steven E. Cwirla - Menlo Park CA
Christian M. Gates - Santa Cruz CA
Peter J. Schatz - Mountain View CA
Palaniappan Balasubramanian - Cupertino CA
Christopher R. Wagstrom - Los Altos CA
Richard Wayne Hendren - Cary NC
Randolph B. Deprince - Raleigh NC
Surekha Podduturi - San Jose CA
Qun Yin - Sunnyvale CA
Assignee:
Glaxo Group Limited - Greenford
International Classification:
A61K 3819
US Classification:
424 141, 424 851, 4241931, 4241941, 42419511, 424 96, 530402, 514 14
Abstract:
Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

Compounds Having Affinity For The Granulocyte-Colony Stimulating Factor Receptor (G-Csfr) And Associated Uses

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US Patent:
6716811, Apr 6, 2004
Filed:
Jul 20, 2000
Appl. No.:
09/620091
Inventors:
Steven E. Cwirla - Menlo Park CA
Palani Balu - Cupertino CA
David J. Duffin - Durham NC
Sunila Piplani - Mountain View CA
Barbara McEowen Merrill - Durham NC
Peter J. Schatz - Cupertino CA
Assignee:
Affymax, Inc. - Palo Alto CA
International Classification:
A01N 4304
US Classification:
514 2, 514 12, 514 13, 514 14, 530350, 530324
Abstract:
Novel compounds are provided that bind to G-CSFR. The novel compounds have a peptide chain approximately 6 to 40 amino acids in length that binds to G-CSFR. The compounds are useful as probes for affinity screening. In addition, the compounds have demonstrated agonist or antagonist activity for the G-CSFR, and are therefore useful in treatment of diseases including patients who suffer from a low white blood cell titer. Pharmaceutical compositions and methods of use are provided as well.

Epitope-Captured Antibody Display

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US Patent:
6777239, Aug 17, 2004
Filed:
Apr 17, 2002
Appl. No.:
10/125062
Inventors:
William J. Dower - Menlo Park CA
Steven E. Cwirla - Menlo Park CA
Assignee:
XenoPort, Inc. - Santa Clara CA
International Classification:
G01N 3353
US Classification:
436 6, 435 71, 435 78, 435 914, 435471, 435489, 536 231, 536 234, 536 235
Abstract:
Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is expressed from a heterologous nucleic acid borne by the package, and one or more antibodies complexed with the expressed protein and which have an open binding site for a target protein. Thus, a segment of the nucleic acid encodes for an epitope that is shared by the expressed polypeptide and the target protein. The reagents can be utilized individually or as part of a library or an array to bind target proteins within protein samples to form one or more complexes. By determining the sequence of the segment of the heterologous nucleic acid of a package within a complex, one can identify the target protein since the segment encodes for an epitope that is shared by the expressed and target proteins.

Compounds Displayed On Replicable Genetic Packages And Methods Of Using Same

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US Patent:
7037706, May 2, 2006
Filed:
Sep 29, 2000
Appl. No.:
09/675525
Inventors:
Ronald W. Barrett - Saratoga CA, US
William J. Dower - Menlo Park CA, US
Mark Gallop - Los Altos CA, US
Thomas F. Woiwode - Menlo Park CA, US
Steven E. Cwirla - Menlo Park CA, US
Assignee:
Xenoport, Inc. - Palo Alto CA
International Classification:
C12N 7/01
C12N 15/00
C12N 15/09
C12N 15/70
C07H 21/04
US Classification:
4352351, 4353201, 435 71, 435 6, 536 231
Abstract:
Replicable genetic packages and collections thereof that display various compounds are provided. In some instances, the replicable genetic packages include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the replicable genetic package. The invention further provides a number of different methods for using the replicable genetic packages to screen a library of compounds for a desired biological activity.

Peptides And Compounds That Bind To A Receptor

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US Patent:
7091311, Aug 15, 2006
Filed:
Feb 27, 2002
Appl. No.:
10/083768
Inventors:
William J. Dower - Menlo Park CA, US
Ronald W. Barrett - Saratoga CA, US
Steven E. Cwirla - Menlo Park CA, US
David J. Duffin - East Palo Alto CA, US
Christian M. Gates - Morgan Hill CA, US
Sherril S. Haselden - Santa Cruz CA, US
Larry C. Mattheakis - Cupertino CA, US
Peter J. Schatz - Mountain View CA, US
Christopher R. Wagstrom - Los Altos CA, US
Nicholas C. Wrighton - Palo Alto CA, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C07K 7/50
US Classification:
530317, 530326, 530327, 530328, 424 169
Abstract:
Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

Array-Based Epitope-Captured Antibody Display

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US Patent:
7192720, Mar 20, 2007
Filed:
Jul 27, 2004
Appl. No.:
10/900857
Inventors:
William J. Dower - Menlo Park CA, US
Steven E. Cwirla - Menlo Park CA, US
Assignee:
XenoPort, Inc. - Santa Clara CA
International Classification:
G01N 33/53
US Classification:
435 71, 435 6, 435 78, 435 914, 435 691
Abstract:
Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is expressed from a heterologous nucleic acid borne by the package, and one or more antibodies complexed with the expressed protein and which have an open binding site for a target protein. Thus, a segment of the nucleic acid encodes for an epitope that is shared by the expressed polypeptide and the target protein. The reagents can be utilized individually or as part of a library or an array to bind target proteins within protein samples to form one or more complexes. By determining the sequence of the segment of the heterologous nucleic acid of a package within a complex, one can identify the target protein since the segment encodes for an epitope that is shared by the expressed and target proteins.

Compounds Displayed On Icosahedral Phage And Methods Of Using Same

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US Patent:
7229757, Jun 12, 2007
Filed:
Mar 21, 2002
Appl. No.:
10/105029
Inventors:
Ronald W. Barrett - Saratoga CA, US
William J. Dower - Menlo Park CA, US
Mark Gallop - Los Altos CA, US
Thomas F. Woiwode - San Carlos CA, US
Steven E. Cwirla - Menlo Park CA, US
Assignee:
Xenoport, Inc. - Santa Clara CA
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen a library of compounds for a desired biological activity are also provided, especially assays for compounds that are substrates for receptor-mediated transport processes such as endocytosis and transcytosis.
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Steven E Cwirla from Menlo Park, CA, age ~63 Get Report