Inventors:
Richard W. Scott - Wallingford PA
Andrew G. Reaume - West Chester PA
Stephen P. Trusko - Avondale PA
Robert Siman - Wilmington DE
Assignee:
Cephalon, Inc. - West Chester PA
International Classification:
C12N 500
C12N 1500
A61K 4900
Abstract:
Disclosed is non-human mouse homozygous for a targeted amyloid precursor protein-encoding gene comprising: (1) a human A. beta. peptide-encoding sequence in place of the native A. beta. peptide-encoding sequence; and (2) Swedish FAD mutations.