Inventors:
Zhaoxia YANG - Whitehouse Station NJ, US
Stephan REILING - Califon NJ, US
Thaddeus NIEDUZAK - Bridgewater NJ, US
Rose M. MATHEW - Ringoes NJ, US
Sharon JACKSON - Whitehouse Station NJ, US
Keith John HARRIS - Chester NJ, US
International Classification:
A61K 31/404
C07D 209/18
C07D 209/20
C07D 257/06
A61K 31/41
A61P 17/00
A61P 37/08
A61K 31/496
A61K 31/435
US Classification:
51425504, 548494, 548496, 548251, 514419, 514381, 514290
Abstract:
The present invention is directed to 2-phenyl-indole compounds, their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, eczema, urticaria diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.