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Srinivas Nomula Phones & Addresses
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Houston, TX
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2216 Edward Stec Blvd, Edison, NJ 08837
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Foster City, CA
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Durham, NC
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Piscataway, NJ
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Parsippany, NJ
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Fort Walton Beach, FL
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Iselin, NJ
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Phoenix, AZ
Resumes
Resumes
Srinivas Nomula
View pagePublications
Us Patents
Polymer Brushes For Immobilizing Molecules To A Surface Or Substrate Having Improved Stability
View pageUS Patent:
7205161, Apr 17, 2007
Filed:
Jan 10, 2002
Appl. No.:
10/043394
Inventors:
Gerrit Klaerner - Campbell CA, US
Didier Benoit - San Jose CA, US
Dominique Charmot - Los Gatos CA, US
Srinivas Nomula - San Jose CA, US
Marcelo Eduardo Piotti - San Jose CA, US
Laura T. Mazzola - Redwood City CA, US
Didier Benoit - San Jose CA, US
Dominique Charmot - Los Gatos CA, US
Srinivas Nomula - San Jose CA, US
Marcelo Eduardo Piotti - San Jose CA, US
Laura T. Mazzola - Redwood City CA, US
Assignee:
Symyx Technologies, Inc. - Santa Clara CA
International Classification:
G01N 33/545
G01N 33/552
C07K 17/08
G01N 33/552
C07K 17/08
US Classification:
436531, 435 6, 436527, 436532, 5303911, 530402, 530404, 530405, 530406
Abstract:
Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.