US Patent:
20190307812, Oct 10, 2019
Inventors:
- Marietta GA, US
Somaly Sith - Marietta GA, US
Tom Koob - Marietta GA, US
Assignee:
MiMedx Group, Inc. - Marietta GA
International Classification:
A61K 35/51
A61K 9/00
C12N 5/078
A61K 9/16
A61K 9/14
Abstract:
The present invention provides compositions and formulations of micronized Wharton's jelly having a controlled viscosity such that when delivered to the injured region of a subject, it remains substantially localized with little or no migration out of the injured region for the repair and/or regeneration thereof. Micronized Wharton's Jelly can be suspended in a pharmaceutically acceptable aqueous carrier, such as saline, sterile water, or any suitable buffer, to form a suspension or a gelatinous gel composition, or it can be in the form of a paste, suitable for delivery into the space adjacent the articular surface cartilage injured region of a subject. The micronized Wharton's jelly when employed at sufficient concentrations can be hydrated into a gel or paste and administered topically, or it can be injected into the body through the use of a needle and syringe. Accordingly, micronized Wharton's Jelly, compositions, or formulations thereof, can be delivered in a manner that is more convenient than Wharton's jelly that has not been micronized in accordance with the present invention.