Siu Y Wong

20180271953, Sep 27, 2018

Jan 19, 2016

15/544618

- Boston MA, US
Siu Ling WONG - Brookline MA, US
Kimberly Lindsay MARTINOD - Kortrijk,, BE
Luise ERPENBECK - Göttingen, DE
Jörn Thilo WITSCH - FREIBURG, DE
Alexander SAVCHENKO - Boston MA, US

THE CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

A61K 38/46
A61K 45/06

Embodiments of the technology described herein are based, in part, upon the discovery that NETosis, the formation of neutrophil extracellular traps (NETs) is increased in wounds, in organ fibrosis and in subjects with diabetes. Accordingly, methods for treating wounds, fibrosis and NET associated complications in diabetes are provided. The methods comprise administrating a therapeutically effective amount of at least one anti-NET compound to a subject in need of treatment, e.g. a PAD 4 inhibitor, a DNase, a histone-degrading enzyme; an inhibitor of chromatin decondensation; an antibody against a component of a NET; an inhibitor of NET release, a protease inhibitor, or an elastase inhibitor.