Simon E Kozin

20230063696, Mar 2, 2023

Oct 11, 2022

18/045739

- Acton MA, US
Ian MCLAUGHLIN - Groton MA, US
Daniel ALLIS - Boxford MA, US
Simon KOZIN - Lexington MA, US
Maureen MCCAFFREY - Arlington MA, US

A61M 5/315
A61M 5/142
A61M 5/145
A61M 5/20

Systems and methods for monitoring an operational state and/or a fill status of a drug container of a drug delivery device are provided. The drug container can hold a liquid drug. A plunger can be positioned within the drug container. A drive system can advance the plunger to expel the liquid drug from the container. A monitoring system can detect a movement and/or a position of the plunger and/or any component coupled to the plunger. The detection can enable determination of an amount of liquid drug that has been expelled and/or an amount of liquid drug remaining in the drug container. Dosing rates, flow rates, and dosage completion can also be determined.

20210379293, Dec 9, 2021

Aug 23, 2021

17/408523

- Acton MA, US
Ian MCLAUGHLIN - Groton MA, US
Simon KOZIN - Lexington MA, US
Maureen MCCAFFREY - Arlington MA, US
Jackie MAC - Malden MA, US
Alexander DOUDOUMOPOULOS - Boxborough MA, US
Bhavin PATEL - Franklin Park NJ, US

A61M 5/315
A61M 5/142
A61M 5/28
A61M 5/32

A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

20210214222, Jul 15, 2021

Jan 11, 2021

17/146468

- Waltham MA, US
Christopher Miles - Acton MA, US
Gregory W. Hall - Belmont MA, US
Simon E. Kozin - Lexington MA, US
Wolfgang Scholz - Beverly MA, US
Frank Heirtzler - Londonderry NH, US

C01B 21/32

Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NOfrom the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system.

20200376191, Dec 3, 2020

Aug 17, 2020

16/995527

- Acton MA, US
Simon KOZIN - Lexington MA, US
Maureen MCCAFFREY - Boston MA, US

A61M 5/145
A61M 5/142
A61M 5/168

Ratchet-based drive systems for more reliable and safer drug delivery are provided. The ratchet-based drive systems restrict angular movement and/or linear movement of components that cause a plunger to expel a liquid drug from a drug container. Movement of the components can be restricted to correspond to a predetermined or desired portion of the liquid drug. In the case that control of the drive system is lost or fails, the maximum amount of drug that could be delivered is limited to a known amount, thereby reducing the likelihood of an overdose.

20200179608, Jun 11, 2020

Feb 19, 2020

16/794689

- Acton MA, US
David NAZZARO - Groveland MA, US
Ian MCLAUGHLIN - Groton MA, US
Simon KOZIN - Lexington MA, US

A61M 5/28
A61M 5/24
A61M 5/34
A61M 5/32
A61M 5/315
A61M 5/142

Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.

20190358409, Nov 28, 2019

Aug 7, 2019

16/534376

- Acton MA, US
Ian MCLAUGHLIN - Groton MA, US
Daniel ALLIS - Boxford MA, US
Simon KOZIN - Lexington MA, US
Maureen MCCAFFREY - Boston MA, US

Insulet Corporation - Acton MA

A61M 5/315
A61M 5/145
A61M 5/142
A61M 5/20

Systems and methods for monitoring an operational state and/or a fill status of a drug container of a drug delivery device are provided. The drug container can hold a liquid drug. A plunger can be positioned within the drug container. A drive system can advance the plunger to expel the liquid drug from the container. A monitoring system can detect a movement and/or a position of the plunger and/or any component coupled to the plunger. The detection can enable determination of an amount of liquid drug that has been expelled and/or an amount of liquid drug remaining in the drug container. Dosing rates, flow rates, and dosage completion can also be determined.

20190091404, Mar 28, 2019

Sep 24, 2018

16/140186

- Acton MA, US
Ian MCLAUGHLIN - Boxboro MA, US
Maureen MCCAFFREY - Boston MA, US
Simon KOZIN - Lexington MA, US
Jackie Mac - Malden MA, US

A61M 5/20
A61M 5/315

A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.

20180256823, Sep 13, 2018

May 15, 2018

15/980469

- Billerica MA, US
Ian MCLAUGHLIN - Boxboro MA, US
Simon KOZIN - Lexington MA, US
Maureen MCCAFFREY - Boston MA, US
Jackie MAC - Malden MA, US
Alexander DOUDOUMOPOULOS - Los Angeles CA, US
Bhavin PATEL - Billerica MA, US

A61M 5/315
A61M 5/28
A61M 5/31
A61M 37/00

A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.