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Simon J Hocart

from New Orleans, LA
Age ~70
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Also known as:
Simon Dr Hocart, Simon James Hocart
Phone and address:
4222 S Rocheblave St, New Orleans, LA 70125
Connected to:
Nowell Hocbo, 40Ellen D Hocevar, 72Helen P Hocevar, 69Scott F Hocevar, 67Agnew R Hoch, 94Bryce A Hoch, 36Callie A Hoch, 55Daniela A Hoch, 43Eric J Hoch, 65Faye S Hoch, 89

Simon Hocart Phones & Addresses

  • 4222 S Rocheblave St, New Orleans, LA 70125
  • 522 Emerald St, New Orleans, LA 70124 (504) 282-1251
  • Mauldin, SC
  • Houston, TX

Resumes

Resumes

Simon Hocart Photo 1

Ama De Casa

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Location:
New Orleans, LA
Industry:
Higher Education
Work:
Uruguay
Ama De Casa
Tulane University 1982 - 2013
Research Professor of Medicine
Tulane University 1982 - 2013
Professor
Simon Hocart Photo 2

Research Professor Of Medicine At Tulane University

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Location:
Greater New Orleans Area
Industry:
Research
Experience:
Tulane University (Educational Institution; 1001-5000 employees; Research industry): Research Professor of Medicine,  (-) 

Publications

Us Patents

Ghrelin/Growth Hormone Releasing Peptide/Growth Hormone Secretatogue Receptor Antagonists And Uses Thereof

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US Patent:
8536120, Sep 17, 2013
Filed:
Apr 30, 2007
Appl. No.:
12/298826
Inventors:
Cyril Y. Bowers - New Orleans LA, US
Gloria S. Tannenbaum - Hampstead, CA
David H. Coy - New Orleans LA, US
Simon J. Hocart - New Orleans LA, US
Assignee:
The Administrators of The Tulane Educational Fund - New Orleans LA
International Classification:
A61K 31/15
A61K 31/216
A61K 38/08
C07K 7/06
US Classification:
514 48, 514 53, 514 69, 514 218, 514510, 514640, 530329, 560 45, 564256
Abstract:
The present invention provides novel compounds that have been demonstrated to be modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, iso forms and variants thereof). These compounds are useful as antagonists of the ghrelin receptor as well as inverse agonist, partial agonist or a combination of these activities as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, diabetes, central nervous system disorders, genetic disorders, and hyperproliferative disorders.

Methods Of Inhibiting The Ghrelin/Growth Hormone Secretatogue Receptor Pathway And Uses Thereof

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US Patent:
20120135918, May 31, 2012
Filed:
May 12, 2010
Appl. No.:
13/320408
Inventors:
Cyril Y. Bowers - New Orleans LA, US
David H. Coy - New Orleans LA, US
Simon J. Hocart - New Orleans LA, US
Gloria S. Tannenbaum - Hampstead, CA
Assignee:
MCGILL UNIVERSITY - Montreal QC
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND - New Orleans LA
International Classification:
A61K 38/08
A61K 31/454
A61P 3/10
C07K 7/06
C07K 7/08
A61P 3/04
A61K 31/4965
US Classification:
514 48, 514323, 51425501, 530328, 530327, 514 69
Abstract:
The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin O-acyltransferase (GOAT) inhibitor and/or a ghrelin receptor antagonist to the subject. The invention also provides ghrelin receptor antagonists of formula (VII): A-A-A-Gly-Ser-A-Phe-Leu-A-A-A-A, wherein each of A, A, and Ais independently absent, an amino acid, or an amino protecting group; each of A-A-A, and Ais independently absent or an amino acid; and Ais a serine conjugated with a —C(O)C-Calky or a di-aminopropionic acid conjugated with a —C(O)C-Calkyl group, provided that at least one of A, A, or Ais present.

Growth Hormone Secretatogue Receptor Antagonists And Uses Thereof

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US Patent:
20130172242, Jul 4, 2013
Filed:
Jun 16, 2011
Appl. No.:
13/704052
Inventors:
Cyril Y. Bowers - New Orleans LA, US
David H. Coy - New Orleans LA, US
Simon J. Hocart - New Orleans LA, US
Gloria S. Tannenbaum - Hampstead, CA
Assignee:
MCGILL UNIVERSITY - Montreal QC
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND - New Orleans LA
International Classification:
C07K 7/08
C07K 14/00
C07K 5/08
C07K 7/06
US Classification:
514 48, 530327, 530326, 530325, 530324, 530329, 530328, 530330, 530331, 514 216, 514 215, 514 214, 514 213, 514 69, 514 193
Abstract:
The present invention provides novel peptides that can modulate the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and sub-types, isoforms and variants thereof). These peptides are useful as antagonists of the ghrelin receptor as well as inverse agonist, partial agonist or a combination of these activities as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, diabetes, central nervous system disorders, genetic disorders, and hyperproliferative disorders.

Method For Synthesizing A Peptide Containing A Non-Peptide

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US Patent:
48032611, Feb 7, 1989
Filed:
Jun 27, 1986
Appl. No.:
6/879348
Inventors:
David H. Coy - New Orleans LA
Simon J. Hocart - New Orleans LA
Assignee:
The Administrators of the Tulane Educational Fund - New Orleans LA
International Classification:
A61K 3702
US Classification:
530333
Abstract:
This invention features a method for the solid phase synthesis of non-peptide bonds (CH. sub. 2 --NH) in polypeptide chains. These polypeptides are synthesized by standard procedures and the non-peptide bond synthesized by reacting an amino aldehyde and an amino acid in the presence of NaCNBH. sub. 3. This invention also features somatostatin analogs with non-peptide bonds. This invention further features a solid phase method of chemically modifying a peptide. The method involves synthesizing. alpha. -N-R and side group N-R analogs of peptides, where R is an alkyl or aryl group, by reacting a carbonyl-containing compound and an amino acid in the presence of NaCNBH. sub. 3.

Method For Synthesizing A Peptide Containing A Non-Peptide Bond

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US Patent:
48974455, Jan 30, 1990
Filed:
Mar 4, 1988
Appl. No.:
7/164068
Inventors:
David H. Coy - New Orleans LA
Simon J. Hocart - New Orleans LA
Assignee:
The Administrators of the Tulane Educational Fund - New Orleans LA
International Classification:
C08F28300
A61K 3702
US Classification:
525 5411
Abstract:
This invention features a method for the solid phase synthesis of non-peptide bonds (CH. sub. 2 --NH) in polypeptide chains. These polypeptides are synthesized by standard procedures and the non-peptide bond synthesized by reacting an amino aldehyde and an amino acid in the presence of NaCNBH. sub. 3. This invention also features somatostatin analogs with non-peptide bonds. This invention further features a solid phase method of chemically modifying a peptide. The method involves synthesizing. alpha. -N-R and side group N-R analogs of peptides, where R is a an alkyl or aryl group, by reacting a carbonyl-containing compound and an amino acid in the presence of NaCNBH. sub. 3.

Method For Synthesizing A Peptide Containing A Non-Peptide Bond

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US Patent:
50596535, Oct 22, 1991
Filed:
Dec 6, 1988
Appl. No.:
7/280318
Inventors:
David H. Coy - New Orleans LA
Simon J. Hocart - New Orleans LA
Assignee:
The Administrators of the Tulane Educational Fund - New Orleans LA
International Classification:
C08F28300
C08G 6348
C08G 6391
US Classification:
525 5411
Abstract:
This invention features a method for the solid phase synthesis of non-peptide bonds (CH. sub. 2 --NH) in polypeptide chains. These polypeptides ae synthesized by standard procedures and the non-peptide bond synthesized by reacting an amino aldehyde and an amino acid in the presence of NaCNBH. sub. 3. This invention also features somatostatin analogs with non-peptide bonds. This invention further features a solid phase method of chemically modifying a peptide. The method involves synthesizing. alpha. -N-R and side group N-R analogs of peptides, where R is an alkyl or aryl group, by reacting a carbonyl-containing compound and an amino acid in the presence of NaCNBH. sub. 3.

Methods Of Inhibiting The Ghrelin/Growth Hormone Secretatogue Receptor Pathway And Uses Thereof

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US Patent:
20150031605, Jan 29, 2015
Filed:
Oct 2, 2014
Appl. No.:
14/505101
Inventors:
- New Orleans LA, US
David H. COY - New Orleans LA, US
Simon J. HOCART - New Orleans LA, US
Gloria S. TANNENBAUM - Hampstead, CA
International Classification:
A61K 38/10
A61K 38/08
US Classification:
514 48
Abstract:
The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin O-acyltransferase (GOAT) inhibitor and/or a ghrelin receptor antagonist to the subject. The invention also provides ghrelin receptor antagonists of formula (VII): A-A-A-Gly-Ser-A-Phe-Leu-A-A-A-A, wherein each of A, A, and Ais independently absent, an amino acid, or an amino protecting group; each of A, A, A, and Ais independently absent or an amino acid; and Ais a serine conjugated with a —C(O)C-Calky or a diaminopropionic acid conjugated with a —C(O)C-Calkyl group, provided that at least one of A, A, or Ais present.
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Simon J Hocart from New Orleans, LA, age ~70 Get Report