Inventors:
Jeonghan Park - Whippany NJ, US
Eugene J. Vater - Lyndhurst NJ, US
Shuan Dong - Watchung NJ, US
Tetsuo Iwama - Scotch Plains NJ, US
Ramani R. Raghavan - Lexington MA, US
Hong-Chang Lee - Livingston NJ, US
George S.k. Wong - Summit NJ, US
Assignee:
Schering-Plough Corporation - Kenilworth NJ
International Classification:
C07C 69/74
C07C 229/02
C07C 237/14
C07C 205/15
C07C 205/02
US Classification:
560123, 562505, 564191, 568704, 568924
Abstract:
Disclosed is a process for preparing 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide hydrochloride, an intermediate useful in the preparation of the HCV protease inhibitor (1R,5S)—N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide.