Inventors:
Joffre B. Baker - Montara CA, US
Drew Watson - Los Altos CA, US
Tara Maddala - Redwood City CA, US
Steven Shak - Hillsborough CA, US
David J. Mauro - Redwood City CA, US
Shirin K. Ford - Redwood City CA, US
Assignee:
Genomic Health, Inc. - Redwood City CA
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12Q 1/68
Abstract:
The present invention provides methods and compositions to facilitate determining whether an EGFR-expressing cancer in an individual is an EGFR inhibitor-responsive cancer, as well as methods for determining the likelihood that a patient having an EGFR-expressing cancer will exhibit a beneficial response to an EGFR inhibitor therapy. The methods generally involve determining a normalized expression level of a gene product that correlates with EGFR inhibitor responsiveness.