Sharon D. Real - San Diego CA David R. Kronenthal - Yardley PA
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D21160
US Classification:
546208
Abstract:
A process is provided for preparing intermediates of the structure ##STR1## wherein Rpg is preferably. dbd. CHC. sub. 6 H. sub. 5 ; and P. G. is a protecting group CBZ or BOC, wherein a protected guanylpyrazole is reacted with an azacycloalkyl, azacycloalkenyl or azaheteroalkyl derivative (such as a piperidine derivative) in the presence of a DBU catalyst. The resulting intermediate may be used as a starting material for preparing thrombin inhibitors.
Sharon D. Real - Pennington NJ David R. Kronenthal - Yardley PA
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D49308
US Classification:
549300
Abstract:
A method is provided for preparing a chiral benzaldehyde of the structure ##STR1## by acylating an anhydride of the structure ##STR2## with a chiral oxazolidine of the structure ##STR3## where Q is MgHal or Li, and X, Y and Z are as described herein, to form a keto acid which is reduced and cyclized. The resulting benzaldehyde may be used in making the final anti-thrombotic - anti-vasospastic compounds. Novel intermediates are also provided.
Benzaldehyde Intermediates Useful In The Preparation Of 7-Oxabicycloheptane Carboxylic Acid Prostaglandin Analog Anti-Thrombotic And Anti-Vasospastic Compounds And Method For Preparing Same
Sharon D. Real - Pennington NJ David R. Kronenthal - Yardley PA
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D49308
US Classification:
548215
Abstract:
A method is provided for preparing a chiral benzaldehyde of the structure ##STR1## by acylating an anhydride of the structure ##STR2## with a chiral oxazolidine of the structure ##STR3## where Q is MgHal or Li, and X, Y and Z are as described herein, to form a keto acid which is reduced and cyclized. The resulting benzaldehyde may be used in making the final anti-thrombotic--anti-vasospastic compounds. Novel intermediates are also provided.
- San Diego CA, US Mark Cornell Manning - Johnstown CO, US Brian M. Murphy - Fort Collins CO, US Sharon Real - San Diego CA, US Charles Theuer - San Diego CA, US
The present application relates to formulations of anti-CD105 antibodies, antigen-binding fragments thereof, and uses thereof. Another aspect relates to pre-filled syringes of the formulations of anti-CD105 antibodies or antigen-binding fragments thereof. Another aspect relates to the use of the formulations to reduce one or more signs or symptoms of an angiogenesis-related disorder such as cancers and ophthalmologic diseases.
- San Diego CA, US Mark Cornell Manning - Johnstown CO, US Brian M. Murphy - Fort Collins CO, US Sharon Real - San Diego CA, US Charles Theuer - San Diego CA, US
The present application relates to formulations of anti-CD105 antibodies, antigen-binding fragments thereof, and uses thereof. Another aspect relates to pre-filled syringes of the formulations of anti-CD105 antibodies or antigen-binding fragments thereof. Another aspect relates to the use of the formulations to reduce one or more signs or symptoms of an angiogenesis-related disorder such as cancers and ophthalmologic diseases.