Inventors:
Stephen O'Connor - Lambertville NJ, US
Jeffrey Robl - Newtown PA, US
Saleem Ahmad - Wall NJ, US
Sharon Bisaha - Lambertville NJ, US
Natesan Murugesan - Princeton Juction NJ, US
Khehyong Ngu - Pennington NJ, US
Yan Shi - Flourtown PA, US
Philip Stein - Pennington NJ, US
Nachimuthu Soundararajan - Kendall Park NJ, US
Kenneth Natalie - Flemington NJ, US
Laxma Kolla - Plainsboro NJ, US
Justin Sausker - Middletown CT, US
Sandra Quinlan - West Simsbury CT, US
Junying Fan - Monmouth Junction NJ, US
Dejah Petsch - Ashford CT, US
Zhenrong Guo - East Brunswick NJ, US
International Classification:
A61K031/4745
C07D471/02
Abstract:
Compounds are provided having the following structure and pharmaceutically acceptable salts thereof, wherein R, R, R, R, U, V, W, Y, and n are as defined above, which compounds are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia, dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis as well as Alzheimer's disease and osteoporosis and may be employed as hormone replacement therapy. A method for treating the above diseases employing the above compounds is also provided.