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Sharath K Rai

from Portage, MI
Age ~59

Sharath Rai Phones & Addresses

  • 7291 Hampstead Ln, Portage, MI 49024 (269) 324-0365
  • 4315 Kettle Moraine Dr, Kalamazoo, MI 49048 (269) 344-5020
  • Norwell, MA
  • 30 Yorkshire Dr, Waterford, CT 06385 (860) 444-1260
  • 14040 15Th St, Seattle, WA 98125 (206) 367-3020
  • Fitchburg, WI
  • Madison, WI
  • Groton, CT

Publications

Us Patents

Methods Of Culturing Lawsonia Intracellularis

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US Patent:
20110020909, Jan 27, 2011
Filed:
Oct 14, 2008
Appl. No.:
12/681690
Inventors:
Jonathan Evans - Kalamazoo MI, US
Connie Gebhart - Maple Grove MN, US
Michael John Huether - Lincoln NE, US
Rajendra Krishnan - Portage MI, US
Gregory P. Nitzel - Mattawan MI, US
Sharath K. Rai - Portage MI, US
Catherine J. Streitzel - Kalamazoo MI, US
Assignee:
Pfizer Inc. - Madison NJ
International Classification:
C12N 1/20
US Classification:
4352521
Abstract:
The present invention relates generally to the growth of in non-mammalian cells and the production of the bacteria on a large scale.

Jaagsiekte Sheep Retroviral Packaging Cell Lines And Methods Relating Thereto

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US Patent:
20030104357, Jun 5, 2003
Filed:
Mar 29, 2002
Appl. No.:
10/112178
Inventors:
Sharath Rai - Waterford CT, US
Arthur Miller - Seattle WA, US
Assignee:
Fred Hutchinson Cancer Research Center - Seattle WA
International Classification:
C12Q001/70
C12P021/06
C12P019/34
A61K039/12
A61K039/21
US Classification:
435/005000, 424/208100, 435/091100, 435/069100, 424/204100
Abstract:
The present invention demonstrates that JSRV envelope protein (Env) can be used to transduce human and other mammalian cells. Hybrid retrovirus packaging cells have been constructed that express the JSRV Env and retrovirus Gag-Pol proteins, and can produce JSRV-pseudotype vectors at high titers. Using high-titer virus the host range for JSRV has been established, and included sheep, human, monkey, bovine and dog cells, but not murine, rat or hamster cells. Retroviral packaging cell lines comprising the JSRV envelope protein, and receptor binding fragments thereof, are provided which transiently and stably produce high titers of recombinant retrovirus particles which can be used to transfer a heterologous gene to a eukaryotic cell.

Ehrlichia Vaccines And Immunogenic Compositions

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US Patent:
20220356231, Nov 10, 2022
Filed:
Jul 13, 2020
Appl. No.:
17/626866
Inventors:
- Carson City NV, US
- Parsippany NJ, US
Suman MAHAN - Kalamazoo MI, US
Jason J. MILLERSHIP - Kalamazoo MI, US
Duncan M. MWANGI - Kalamazoo MI, US
Sharath RAI - Kalamazoo MI, US
Sharon M. WAPPEL - Kalamazoo MI, US
Assignee:
Research Development Foundation - Carson City NV
Zoetis Services LLC - Parsippany NJ
International Classification:
C07K 16/12
C07K 14/29
Abstract:
Provided herein are immunogenic compositions that may be used, in some aspects, to induce an immune response against an such as cams. In some embodiments, the immunogenic composition comprises an E. canis bacterin and/or adjuvant, such as for example an emulsion or liposomal adjuvant. Related methods such as for diagnosis of or vaccination against ehrlichiosis are also provided.

Methods And Composition For Induction Of Immune Response

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US Patent:
20230100089, Mar 30, 2023
Filed:
Apr 28, 2022
Appl. No.:
17/731348
Inventors:
- Parsippay NJ, US
Duncan Mwangi - Portage MI, US
Joseph M. Bricker - Parsippany NJ, US
Dennis L. Foss - Mattawan MI, US
Sharath K. Rai - Portage MI, US
Suman Mahan - Kalamazoo MI, US
International Classification:
A61K 39/39
A61K 31/704
A61K 45/06
A61K 31/14
A61K 31/575
A61K 31/7028
Abstract:
The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.

Vaccines Against Hendra And Nipah Virus Infection

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US Patent:
20210008195, Jan 14, 2021
Filed:
Dec 18, 2018
Appl. No.:
16/970731
Inventors:
- Parsippany NJ, US
Duncan M. Mwangi - Portage MI, US
Dennis Lee Foss - Mattawan MI, US
Sharath K. Rai - Portage MI, US
John Morgan Hardham - Kalamazoo MI, US
International Classification:
A61K 39/155
A61K 39/39
Abstract:
Disclosed is a method of protecting an animal in need thereof from Hendra or Nipah virus infection comprising administering to said animal a single dose of a vaccine, the vaccine comprising:an antigen component comprising a Hendra antigen or a Nipah antigen; and an adjuvant comprising oil, polycationic carrier and a CpG containing immunostimulatory oligonucleotide, wherein the vaccine is a W/O emulsion.

Oil-Based Adjuvants

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US Patent:
20190038737, Feb 7, 2019
Filed:
Oct 22, 2018
Appl. No.:
16/166455
Inventors:
- Parsippany NJ, US
Dennis L. Foss - Mattawan MI, US
Guillermo Gallo - Kalamazoo MI, US
John Morgan Hardham - Kalamazoo MI, US
Richard Lee Krebs - Ashland NE, US
Sandra Ann Marie Lightle - Kalamazoo MI, US
Suman Mahan - Kalamazoo MI, US
Sangita Mediratta - Kalamazoo MI, US
Kaori Mohr - Kalamazoo MI, US
Duncan Mwangi - Portage MI, US
Sharath K. Rai - Portage MI, US
Sarah A. Salmon - Kalamazoo MI, US
Shaunak Vora - Kalamazoo MI, US
Lauren Wilmes - Lincoln NE, US
International Classification:
A61K 39/09
A61K 39/00
A61K 39/002
A61K 39/012
A61K 39/108
A61K 39/05
A61K 39/08
A61K 39/085
A61K 39/118
A61K 39/12
A61K 39/39
G01N 33/569
Abstract:
The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

Liposomal Adjuvant Compositions

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US Patent:
20180021424, Jan 25, 2018
Filed:
Jul 19, 2016
Appl. No.:
15/213627
Inventors:
Duncan Mwangi - Portage MI, US
Sharath K. Rai - Portage MI, US
Dennis L. Foss - Mattawan MI, US
Traci K. Godbee - Climax MI, US
Laurel Mary Sly - Portage MI, US
Suman Mahan - Kalamazoo MI, US
Shaunak Vora - Portage MI, US
International Classification:
A61K 39/12
A61K 39/39
A61K 39/145
C12N 7/00
A61K 39/002
C12N 15/117
A61K 39/265
Abstract:
The invention provides a liposomal adjuvant composition comprising an external membrane and an internal compartment, the external membrane comprising: a quaternary ammonium compound; a sterol; a phospholipid; and a glycolipid. Vaccine compositions comprising the liposomal adjuvant of the instant invention are also provided.

Methods And Compositions For Induction Of Immune Response

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US Patent:
20180008701, Jan 11, 2018
Filed:
Nov 21, 2014
Appl. No.:
15/039733
Inventors:
- Florham Park NJ, US
Duncan Mwangi - Kalamazoo MI, US
Joseph Bricker - Kalamazoo MI, US
Dennis Foss - Kalamazoo MI, US
Sharath K. Rai - Kalamazoo MI, US
Suman Mahan - Kalamazoo MI, US
International Classification:
A61K 39/39
A61K 39/00
Abstract:
The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.
Sharath K Rai from Portage, MI, age ~59 Get Report