Inventors:
Cathleen Hanau - Chesterfield MO, US
Serena Mershon - Bessemer MI, US
Matthew Graneto - Chesterfield MO, US
Marvin Meyers - St. Charles MO, US
Shridhar Hegde - Ballwin MO, US
Ingrid Buchler - South University City MO, US
Kun Wu - Chesterfield MO, US
Shuang Liu - Schenectady NY, US
Kassoum Nacro - Guiderland NY, US
Assignee:
Pharmacia Corporation - St. Louis MO
International Classification:
A61K031/4439
A61K031/415
US Classification:
514/341000, 514/406000, 546/275400, 548/377100
Abstract:
Compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNF, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.