US Patent:
20090291923, Nov 26, 2009
Inventors:
Gary H. Posner - Baltimore MD, US
Ikhyeon Paik - New Haven CT, US
Kristina Borstnik - State College PA, US
Wonsuk Chang - Baltimore MD, US
Sandra Sinishtaj - Baltimore MD, US
William Malo - Katonah NY, US
John Gaetano D'Angelo - Lindenhurst NY, US
Lauren Elaine Woodard - Abingdon MD, US
Alvin Solomon Kalinda - Baltimore MD, US
Aimee R. Usera - Odenton MD, US
Lindsey Catherine Hess - Baltimore MD, US
Andrew Scott Rosenthal - Baltimore MD, US
Seongho Oh - Cockeysville MD, US
Astrid C. Baege - McLean VA, US
Assignee:
Johns Hopkins Universoty - Baltimore MD
The Government of the United States of America as Represented by the Secretary of the DHHS NIH, Offi - Rockville MD
International Classification:
A61K 31/665
C07D 493/18
C07F 9/6561
A61K 31/357
C07D 495/10
C07D 317/12
C07D 317/22
C07D 493/10
A61P 35/00
C07D 263/12
US Classification:
514100, 549348, 549220, 514450, 549 23, 549430, 549453, 549334, 548239
Abstract:
The invention provides novel trioxane dimers having formulae III, IV or V: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer and/or malaria using these compounds and compositions.