US Patent:
20120301402, Nov 29, 2012
Inventors:
Maqsood Ahmed Chotani - Columbus OH, US
John Anthony Bauer - Westerville OH, US
Mandar Shankar Joshi - Glen Waverly, AU
Selvi Chrysolyte Jeyaraj - Columbus OH, US
Assignee:
NATIONWIDE CHILDREN'S HOSPITAL, INC. - Columbus OH
International Classification:
G01N 33/573
A61K 49/00
A61K 31/4709
A61K 31/166
A61K 31/4402
A61P 9/06
A61K 31/4166
A61K 31/138
A61K 31/4458
A61K 31/5415
A61K 31/24
A61K 31/5377
C12Q 1/02
A61K 31/167
US Classification:
424 92, 435 74, 435 29, 514305, 514619, 514357, 514626, 514391, 514651, 514331, 514652, 5142252, 514538, 5142362
Abstract:
A method for assessing if a subject has or is at risk of developing cardiac arrhythmia is described. The method includes determining the activity of Rap1A protein in a bodily sample of the subject and comparing the activity of Rap1A protein from the bodily sample of the subject to at least one Rap1A control. A decreased level of Rap1A activity in the bodily sample of the subject as compared to the at least one Rap1A control indicates that the subject is at risk of developing or has cardiac arrhythmia. Methods for evaluating the efficacy of treatment of a subject having decreased Rap1A activity with an antiarrhythmic agent are also described.
