Inventors:
Sara Hadida Ruah - La Jolla CA, US
Anna Hazlewood - San Diego CA, US
Peter D. J. Grootenhuis - San Diego CA, US
Fredrick Van Goor - San Diego CA, US
Ashvani Singh - San Diego CA, US
Jinglan Zhou - San Diego CA, US
Jason McCartney - Cardiff-by-the-Sea CA, US
Assignee:
Vertex Pharmaceuticals Incorporated - Cambridge MA
International Classification:
C07D 215/38
Abstract:
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.