Santosh Krishna Putta

8273544, Sep 25, 2012

Apr 8, 2011

13/083156

Wendy J. Fantl - San Francisco CA, US
David B. Rosen - Mountain View CA, US
Alessandra Cesano - Redwood City CA, US
Santosh K. Putta - Foster City CA, US
James R. Hackett - San Jose CA, US
Michael Walker - Mountain View CA, US
Jing Shi - Mountain View CA, US

Nodality, Inc. - South San Francisco CA

G01N 33/53
G01N 33/567
G01N 33/00

435 721, 435 723, 435 724, 435 614

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

8399206, Mar 19, 2013

Oct 22, 2010

12/910769

Wendy J. Fantl - San Francisco CA, US
David B. Rosen - Mountain View CA, US
Alessandra Cesano - Redwood City CA, US
Santosh K. Putta - Foster City CA, US
James R. Hackett - San Jose CA, US
Michael Walker - Mountain View CA, US
Jing Shi - Mountain View CA, US

Nodality, Inc. - South San Francisco CA

G01N 33/53
G01N 33/567
G01N 33/00

435 721, 435 723, 435 724

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

20090098594, Apr 16, 2009

Aug 21, 2008

12/229476

Wendy J. Fantl - San Francisco CA, US
Santosh K. Putta - Foster City CA, US
Omar D. Perez - San Francisco CA, US
Helen L. Francis-Lang - San Francisco CA, US
Aileen C. Cohen - Palo Alto CA, US

Nodality, Inc. - South San Francisco CA

C12Q 1/02

435 29

This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. The physiological status of a cell can be determined by comparing the intracellular status of one or more activation elements (e.g. the phosphorylation status of a signaling molecule) in a cell (e.g. a cancer cell) to that of another cell (e.g. a normal cell). The physiological status of a cell can be further classified by adding one or more modulators (e.g. an inhibitor or activator) to the cell in question. In some embodiments, the invention is directed to methods of determining a phenotypic profile of a population of cells.

20100009364, Jan 14, 2010

Jul 10, 2009

12/460029

Wendy J. Fantl - San Francisco CA, US
David B. Rosen - San Francisco CA, US
Alessandra Cesano - Redwood City CA, US
Santosh K. Putta - Foster City CA, US
Garry Nolan - San Francisco CA, US
Aileen Cohen - Palo Alto CA, US
Erik Evensen - Foster City CA, US

Nodality, Inc. - South San Francisco CA

C12Q 1/68

435 6

The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.

20100014741, Jan 21, 2010

Jul 10, 2009

12/501295

Steven C. Banville - Sunnyvale CA, US
Santosh K. Putta - Foster City CA, US
David C. Spellmeyer - Oakland CA, US

G06T 7/00

382133, 382199

In one embodiment, one or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to receive a set of parameter values defining a boundary within a data space associated with a dataset. The dataset can represent signaling related to a test substance. A first metric can be defined based on a first portion of the dataset associated with a first region defined by the boundary. A second metric can be defined based on a second portion of the dataset associated with a second region defined by the boundary after the boundary is modified. The second region can be different than the first region.

20100030719, Feb 4, 2010

Aug 10, 2009

12/538643

Todd M. Covey - San Carlos CA, US
Erik Evensen - Foster City CA, US
Santosh K. Putta - Foster City CA, US

G06N 5/02
G06F 17/30

706 48, 7071041, 707E17044

In one embodiment, one or more processor-readable media can be configured to store code representing instructions that when executed by one or more processors can cause the one or more processors to select a first relationship rule based on a first combination of parameters including a first parameter, and based on a hierarchical position of the first parameter within a hierarchical structure of a set of parameters from a biological category. A first statistical value can be defined based on a plurality of test values and based on the first relationship rule. A second statistical value can be defined based on a second relationship rule and based on a second combination of parameters. The second relationship rule can be selected based on a hierarchical position of the second parameter within the hierarchical structure of the set of parameters.

20100042351, Feb 18, 2010

Jul 10, 2009

12/501274

Todd M. Covey - San Carlos CA, US
Darwin A. Farrow - Castro Valley CA, US
Barton J. Friedland - San Francisco CA, US
Helen Francis-Lang - Devon, GB
Malcolm Francis-Lang - , US
Justin W. Mccarthy - San Francisco CA, US
Santosh K. Putta - Foster City CA, US
David B. Rosen - Mountain View CA, US
David M. Soper - San Francisco CA, US
David C. Spellmeyer - Oakland CA, US

G06F 19/00

702108

In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.

20120215481, Aug 23, 2012

Feb 17, 2012

13/399489

Todd M. Covey - San Carlos CA, US
Darwin A. Farrow - Castro Valley CA, US
Barton J. Friedland - San Francisco CA, US
Helen Francis-Lang - Deven, GB
Malcolm Francis-Lang - Devon, GB
Justin W. Mccarthy - San Francisco CA, US
Santosh K. Putta - Foster City CA, US
David B. Rosen - Mountain View CA, US
David M. Soper - San Francisco CA, US
David C. Spellmeyer - Oakland CA, US

Nodality, Inc. - South San Francisco CA

G06F 19/00

702123

In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.