Sandor Barcza

48249505, Apr 25, 1989

Sep 3, 1987

7/092834

Sandor Barcza - Mountain Lakes NJ

Sandoz Pharm. Corp. - E. Hanover NJ

C07F 702
C07F 710
C07F 708
C07F 506

546 14

This invention relates to chiral compositions.

42084083, Jun 17, 1980

Nov 30, 1978

5/965021

Sandor Barcza - West Orange NJ

Sandoz, Inc. - E. Hanover NJ

C07F 710

424184

This disclosure describes novel compounds of the formula: ##STR1## where R. sub. 1 and R. sub. 2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, lower alkoxy, trifluoromethyl or R. sub. 1 is ##STR2## and R. sub. 2 is hydrogen, wherein R. sub. 7 and R. sub. 8 are each independently hydrogen or lower alkyl and n is 0 or 1, and R. sub. 3, R. sub. 4, R. sub. 5 and R. sub. 6 each independently represent lower alkyl, which are useful as muscle relaxants.

41327250, Jan 2, 1979

Feb 27, 1978

5/881686

Sandor Barcza - West Orange NJ

Sandoz, Inc. - East Hanover NJ

C07F 710

2604482N

Benzazasilin-4-ones of the formula ##STR1## where R. sub. 1 represents H or alkyl of 1-5 carbon atoms, R. sub. 2 represents alkyl of 1-5 carbon atoms, R. sub. 3 represents alkyl of 1-5 carbon atoms or ##STR2## where R. sub. 5 represents H, alkyl of 1-5 carbon atoms, halo having an atomic weight of about 19-36, alkoxy having 1-5 carbon atoms, or ##STR3## where R. sub. 6 and R. sub. 7 each, independently, represent alkyl having 1-2 carbon atoms, and R. sub. 4 represents alkyl having 1-3 carbon atoms, e. g. , 1-(p-chlorophenyl)-2,3-dihydro-1,3-dimethyl-3,1-benzazasilin-4(1H)-one, are prepared from the appropriate lithiated N-alkyl benzamide and a halomethyl halosilane and are useful as antiobesity agents or sleep inducers.

40976092, Jun 27, 1978

Mar 2, 1977

5/773535

Sandor Barcza - West Orange NJ
James B. Hendrickson - Cambridge MA

Sandoz, Inc. - E. Hanover NJ

C07C 4982
A01N 924

424331

2,4-Disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrenes e. g. , 2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene are useful as hypolipidemic agents.

43741304, Feb 15, 1983

Jan 22, 1981

6/227179

Sandor Barcza - Mountain Lakes NJ

Sandoz, Inc. - East Hanover NJ

A61K 31695

424184

This disclosure describes compounds of the formula ##STR1## wherein n is 3, 5 or 7, and each R is lower alkyl having 1 to 4 carbon atoms, or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents in particular glucagon inhibiting agents.

39766845, Aug 24, 1976

Apr 4, 1975

5/565065

Sandor Barcza - West Orange NJ

Sandoz, Inc. - E. Hanover NJ

C07C 6520

2605145

1-succinoyl-2,4-disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthre nes, e. g. , 1-succinoyl-2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene are prepared by treating a corresponding 2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene with a Friedel Crafts catalyst in the presence of an organic solvent, and are useful as hypolipidemic agents.

40340457, Jul 5, 1977

Dec 4, 1975

5/637718

Sandor Barcza - West Orange NJ
James B. Hendrickson - Cambridge MA

Sandoz, Inc. - E. Hanover NJ

C07C 4982

260590FB

2,4-Disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrenes e. g. , 2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene are useful as hypolipidemic agents.

41750918, Nov 20, 1979

Feb 27, 1978

5/881687

Sandor Barcza - West Orange NJ

Sandoz, Inc. - E. Hanover NJ

C07F 710

2604482N

Compounds of the following structure ##STR1## where R. sub. 1 represents H or alkyl having 1-5 carbon atoms, R. sub. 2, R. sub. 3, R. sub. 4 and R. sub. 5 each, independently represents H or alkyl having 1-2 carbon atoms R. sub. 6 represents H, alkyl having 1-5 carbon atoms, halo, alkoxy having 1-5 carbon atoms or ##STR2## where R. sub. 8 and R. sub. 9 each, independently, represent alkyl having 1-2 carbon atoms, and R. sub. 7 represents alkyl having 1-5 carbon atoms, e. g. , 1-(p-chlorophenyl)-1,4-dihydro-. beta. ,. beta. ,1-trimethyl-3,1-benzazasiline -3(2H)-ethanol, are prepared from corresponding oxazolo benzazasilanes by reduction with borohydride, and are useful as sleep inducers.