US Patent:
20090100532, Apr 16, 2009
Inventors:
Ryan Drenan - Pasadena CA, US
Henry A. Lester - South Pasadena CA, US
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasedena CA
International Classification:
A01K 67/027
US Classification:
800 3, 800 13, 800 15, 800 16, 800 19, 800 18, 800 25
Abstract:
Provided herein are transgenic non-human animals having a transgene encoding a variant nicotinic acetylcholine receptor (nAChR) subunit, wherein the variant nAChR subunit is selected from the group consisting of α6, α5, and β2. The transgenic animals display a modified phenotype that includes nicotinic hypersensitivity. Also provided are methods of generating the invention transgenic animals. Further provided are methods for screening a candidate agent for the ability to modulate nicotine-mediated behavior in the invention transgenic animals.