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Ryan Drenan Phones & Addresses

  • 5369 Summer Hill Ln, Winston Salem, NC 27106 (847) 427-9660
  • Mount Prospect, IL
  • 3708 Dartmouth Pl, West Lafayette, IN 47906 (765) 463-7777
  • Glendale, CA
  • 6018 Mcpherson Ave, Saint Louis, MO 63112
  • Pasadena, CA
  • San Diego, CA

Publications

Us Patents

Transgenic Mice Expressing Hypersensitive Nicotinic Receptors

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US Patent:
20090100532, Apr 16, 2009
Filed:
Sep 24, 2008
Appl. No.:
12/237310
Inventors:
Ryan Drenan - Pasadena CA, US
Henry A. Lester - South Pasadena CA, US
Assignee:
CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasedena CA
International Classification:
A01K 67/027
US Classification:
800 3, 800 13, 800 15, 800 16, 800 19, 800 18, 800 25
Abstract:
Provided herein are transgenic non-human animals having a transgene encoding a variant nicotinic acetylcholine receptor (nAChR) subunit, wherein the variant nAChR subunit is selected from the group consisting of α6, α5, and β2. The transgenic animals display a modified phenotype that includes nicotinic hypersensitivity. Also provided are methods of generating the invention transgenic animals. Further provided are methods for screening a candidate agent for the ability to modulate nicotine-mediated behavior in the invention transgenic animals.
Ryan M Drenan from Winston Salem, NC, age ~46 Get Report