US Patent:
20040265337, Dec 30, 2004
Inventors:
Krisztina Zsebo - La Jolla CA, US
Roymarie Ballester - Santa Barbara CA, US
Gary Schoolnik - Palo Alto CA, US
Steven Julio - Santa Barbara CA, US
Andrew Giusti - San Diego CA, US
International Classification:
A61K039/02
Abstract:
This invention provides immunogenic compositions containing attenuated bacteria (such as ) which are resistant to the antimicrobial actions of human defensins, particularly human defensin 5 (HD-5). Methods for using these compositions to elicit a sustained and highly specific immune response are provided. The invention also provides methods for preparing vaccines wherein a heterologous antigen is expressed by the defensin-resistant bacteria.