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Royce Mohan

from West Hartford, CT
Age ~62
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Related to:
Casey J Mcmahon, 43John Mcmahon Casey, 43Krystina CirilliHolly L Mohan, 52Jacqueline Casey, 89Mary K Cirilli, 45Diane Casey, 58
Connected to:
Alice K Mohan, 37Anisha M Mohan, 43Ann M Mohan, 99Asha Mohan, 58Aswath Mohan, 49Avik B Mohan, 30Bob A Mohan, 40Bonny Mohan, 57Chandra R Mohan, 75Christopher Mohan, 43

Royce Mohan Phones & Addresses

  • 178 Auburn Rd, West Hartford, CT 06119 (860) 231-8892
  • 2006 Baltimore Rd, Rockville, MD 20851 (301) 251-5132 (301) 340-6956 (301) 610-0859
  • 4320 Contessa Ct, Lexington, KY 40515 (859) 245-3707
  • 3901 Rapid Run Dr, Lexington, KY 40515 (859) 245-3707
  • 3901 Rapid Run Dr APT 922, Lexington, KY 40515 (859) 245-3707
  • 112 Saint Lawrence Dr, Silver Spring, MD 20901 (301) 593-0682
  • Farmington, CT
  • Boston, MA
  • Hamden, CT

Publications

Us Patents

Withanolide Compounds As Inhibitors Of Fibrosis And Identification Of Molecular Targets For Anti-Fibrotic Drug Development

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US Patent:
8283323, Oct 9, 2012
Filed:
Mar 13, 2007
Appl. No.:
11/724053
Inventors:
Royce Mohan - Lexington KY, US
Assignee:
University of Kentucky Research Foundation - Lexington KY
International Classification:
A61P 27/02
A61K 36/185
US Classification:
514 208, 514169, 435 15, 435 29, 424725, 548454
Abstract:
Provided are methods for screening for drugs effective for treating fibrotic conditions. One screening method comprises exposing a cell to a test compound, monitoring the effect of the test compound on the amount or form of a cell molecule, comparing the amount or form of the cell molecule with the result obtained by treatment of the cell with an anti-fibrotic -effective amount of a withanolide compound, and selecting a drug effective for treating a fibrotic disease based on the ability of the test compound to provide the effect obtained by the withanolide compound on the cell molecule. Also provided is a method of treating a fibrotic disease comprising administering an anti-fibrotic effective amount of a withanolide compound to a mammal in need of treatment for fibrosis.

Withanolides, Probes And Binding Targets And Methods Of Use Thereof

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US Patent:
20080207574, Aug 28, 2008
Filed:
Feb 14, 2007
Appl. No.:
11/674947
Inventors:
Royce Mohan - Lexington KY, US
Kyung Bo Kim - Lexington KY, US
International Classification:
A61K 31/58
G01N 33/53
C07K 14/47
C07J 71/00
US Classification:
514172, 435 72, 530402, 540 80, 977774
Abstract:
Novel withanolide chemical genetic probes identify the in vivo binding target of withaferin A, which is the intermediate filament type III protein vimentin. In addition, a withanolide-based small molecule screening method screens drug candidates that target intermediate filament type III proteins. The method includes introducing a tagged linker covalently bonded to the withanolide molecule to form a withanolide probe. Better or alternative small molecule compounds as potential drug candidates can be generated based on their likely affinity for the determined binding site in vimentin. The affinity labeled withanolide can also be used to find intermediate filament-associated proteins using chemical proteomics by extracting proteins from cells that were exposed to withanolide-biotin analog. The withanolide probes can be used to monitor expression of vimentin, in tumor samples or other diseased tissues. Withaferin analogs can be used as a treatment for diverse vimentin-associated disorders, such as cancers, angiofibrotic diseases, and chronic inflammation.
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Royce Mohan from West Hartford, CT, age ~62 Get Report