US Patent:
20060235017, Oct 19, 2006
Inventors:
Pier Cirillo - Woodbury CT, US
Donghong Gao - Hopewell Junction NY, US
Daniel Goldberg - Redding CT, US
Abdelhakim Hammach - Danbury CT, US
Ming-Hong Hao - Ridgefield CT, US
Victor Kamhi - Danbury CT, US
Neil Moss - Ridgefield CT, US
Matthew Netherton - Danbury CT, US
Kevin Qian - New Milford CT, US
Mark Ralph - Beacon Falls NY, US
Lifen Wu - New Milford CT, US
Zhaoming Xiong - Danbury CT, US
Ronald Aungst - Clifton Park NY, US
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT
International Classification:
A61K 31/5377
A61K 31/513
C07D 413/14
C07D 403/14
US Classification:
514235500, 514252190, 514269000, 544295000, 544314000, 544122000
Abstract:
Disclosed are compounds of formula (I) Where Ar, X, Y, Q, W, R, R, R, Rand Rare defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.