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Rolf Karl Swoboda

from Upper Darby, PA
Age ~69
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Also known as:
Rolf K Swoboda, Rolf D Swoboda, Rolf M Swoboda, Rols Swoboda, Robert Swoboda, Rolf Swodoba
Phone and address:
109 Crestview Rd, Kirklyn, PA 19082
(484) 461-8843
Connected to:
Agnes Swoboda, 103Amber Swoboda, 39Bethany J Swoboda, 33Carol S Swoboda, 69Cheri J Swoboda, 72Donna L Swoboda, 93Forrest A Swoboda, 113Janae Swoboda, 40Joseph L Swoboda, 65Karen M Swoboda, 74

Rolf Swoboda Phones & Addresses

  • 109 Crestview Rd, Upper Darby, PA 19082 (484) 461-8843
  • Philadelphia, PA
  • New Orleans, LA
  • Omaha, NE
  • Metairie, LA

Work

Company: The wistar institute - Philadelphia, PA 1999 Position: Senior scientist

Education

School / High School: University of Wrzburg Mar 1987 Specialities: PhD in Immunology and Molecular Biology

Skills

Cell Based Assays • Protein Expression • Cell Biology • Molecular Biology • In Vivo • Genomics • In Vitro • Flow Cytometry • Cancer • Sequence Analysis • Immunology • Pcr • Cell Culture • Dna • Dna Sequencing • Elisa • Sequencing • Western Blotting • Microbiology • Life Sciences • Oncology • Ipsc • Rnaseq • Lentivirus • Peer Reviews • Lifesciences • Cancer Research • Cell • Polymerase Chain Reaction

Languages

English • German

Industries

Research

Resumes

Resumes

Rolf Swoboda Photo 1

Rolf Swoboda

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Location:
Collegeville, PA
Industry:
Research
Work:
Wistar Institute since Nov 1999
Senior scientist
Louisiana State University Medical Center Apr 1998 - Oct 1999
Scientist
Department of Mycology Feb 1994 - Dec 1997
Junior research group leader
University of Aberdeen Jan 1990 - Jan 1994
Senior Postdoctoral Fellow
UCSF Aug 1987 - Dec 1990
Postdoctoral fellow
Education:
Julius-Maximilians-Universität Würzburg 1982 - 1987
Dr. rer. nat, Immunology, molecular biology Julius-Maximilians-Universität Würzburg 1975 - 1980
Diploma (MS), Biology; immunology and microbiology
Skills:
Cell Based Assays
Protein Expression
Cell Biology
Molecular Biology
In Vivo
Genomics
In Vitro
Flow Cytometry
Cancer
Sequence Analysis
Immunology
Pcr
Cell Culture
Dna
Dna Sequencing
Elisa
Sequencing
Western Blotting
Microbiology
Life Sciences
Oncology
Ipsc
Rnaseq
Lentivirus
Peer Reviews
Lifesciences
Cancer Research
Cell
Polymerase Chain Reaction
Languages:
English
German
Rolf Swoboda Photo 2

Rolf Swoboda Upper Darby, PA

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Work:
The Wistar Institute
Philadelphia, PA
1999 to May 2013
Senior scientist
Department of Molecular Biology

1998 to 1999
Scientist
Hans-Knll-Institute

1994 to 1997
Junior research group leader
Education:
University of Wrzburg
Mar 1987
PhD in Immunology and Molecular Biology
University of Wrzburg
Jul 1980
Certificate of Completion of the NIH Research Commercialization in Biology

Publications

Us Patents

Method For Identifying A Mhc Class H-Dependent Tumor Associated T Helper Cell Antigen

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US Patent:
20100303833, Dec 2, 2010
Filed:
Aug 17, 2010
Appl. No.:
12/857960
Inventors:
Dorothee Herlyn - Wynnewood PA, US
Rajasekharan Somasundaram - West Chester PA, US
Rolf K. Swoboda - Upper Darby PA, US
International Classification:
A61K 39/395
A61K 39/00
C07K 16/28
A61P 37/04
A61P 35/00
C40B 20/00
C12N 5/0783
US Classification:
4241731, 4241841, 5303896, 506 2, 435375
Abstract:
The present invention is a method for identifying MHC class II-dependent disease-associated antigens. The instant method involves expressing a library of disease-derived proteins in lytic bacteriophage for subsequent presentation by antigen presenting cells to T helper cells. Disease-associated antigens are provided as are the use of such antigens in vaccines for inducing an immune response and preventing or treating disease. Moreover, the present invention provides antibodies, which specifically bind to MHC class II-dependent disease-associated antigens or epitope peptides thereof, and their diagnostic and therapeutic use.

Method For Identifying A Mhc Class Ii-Dependent Tumor-Associated T Helper Cell Antigen

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US Patent:
20100080792, Apr 1, 2010
Filed:
Jun 15, 2006
Appl. No.:
11/917363
Inventors:
Dorothee Herlyn - Wynnewood PA, US
Rajasekharan Somasundaram - West Chester PA, US
Rolf K. Swoboda - Upper Darby PA, US
International Classification:
A61K 39/395
C40B 20/00
C07K 14/00
A61K 39/00
C12N 5/00
C07K 16/00
A61P 35/00
A61P 31/00
US Classification:
4241301, 506 2, 530350, 4241841, 4242771, 435375, 5303891, 5303897
Abstract:
The present invention is a method for identifying MHC class II-dependent disease-associated antigens. The instant method involves expressing a library of disease-derived proteins in lytic bacteriophage for subsequent presentation by antigen presenting cells to T helper cells. Disease-associated antigens are provided as are the use of such antigens in vaccines for inducing an immune response and preventing or treating disease. Moreover, the present invention provides antibodies, which specifically bind to MHC class II-dependent disease-associated antigens or epitope peptides thereof, and their diagnostic and therapeutic use.

Methods For Generating Bispecific Functional Agents

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US Patent:
20180334666, Nov 22, 2018
Filed:
Jul 10, 2018
Appl. No.:
16/031533
Inventors:
- Pottstown PA, US
Xiaole Chen - Exton PA, US
Christine Mary Prokopowitz - Douglassville PA, US
Rolf Swoboda - Upper Darby PA, US
Ian White - West Chester PA, US
International Classification:
C12N 15/10
C07K 16/00
Abstract:
The present invention provides a method for preparing a modular scaffold that can bind to a target antigen and a method for engineering a bispecific functional agent consisting of an existing polypeptide binder fused at its C-terminus with said modular scaffold.

Triple-Mode System For Antibody Maturation, Surface Display And Secretion

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US Patent:
20180334668, Nov 22, 2018
Filed:
May 22, 2018
Appl. No.:
15/986025
Inventors:
- Pottstown PA, US
Xiaole Chen - Exton PA, US
Hung Pham - Phoenixville PA, US
Christine Mary Prokopowitz - Douglassville PA, US
Rolf Swoboda - Upper Darby PA, US
Ian White - West Chester PA, US
International Classification:
C12N 15/10
C12N 15/81
C12Q 1/6897
C07K 14/705
Abstract:
The present invention provides a triple-mode antibody display system that simultaneously matures, displays and secretes an antibody to a target of interest. An antibody in vivo-matured and complexed with membrane anchored bait can be expressed on the surface of the host cell, while complexed with a soluble bait the antibody is secreted from the host cell. Methods of using the system for identifying binders that bind specifically to an antigen of interest are also provided. Polypeptides, polynucleotides and host cells useful for making the protein binder display system are also provided along with methods of use thereof

Composition And Method For Diversifying Polypeptide Libraries

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US Patent:
20170183645, Jun 29, 2017
Filed:
Dec 15, 2016
Appl. No.:
15/380105
Inventors:
- Pottstown PA, US
Alexander Taylor - Mount Juliet TN, US
Gisela Marquez - Exton PA, US
Christine Prokopowitz - Eagleville PA, US
Rolf Swoboda - Upper Darby PA, US
International Classification:
C12N 15/10
C07K 16/00
C12N 15/81
G01N 33/569
C12N 9/78
Abstract:
Provided, among other things, is a yeast cell comprising: (A) a recombinant DNA that constitutively or inducibly expresses a cytidine deaminase comprising sequence with about 90% sequence identity or more with a cytidine deaminase domain of (i) SEQ ID NO. 2 or SEQ ID NO. 4, or (ii) a chimera between the two starting with SEQ ID NO. 3 or SEQ ID NO. 4 sequence and having one transition to end in SEQ ID NO. 1 or SEQ ID NO. 2 sequence, or (iii) a chimera between the two starting with SEQ ID NO. 1 or SEQ ID NO. 2 sequence and having one transition to end in SEQ ID NO. 3 or SEQ ID NO. 4 sequence; and (B) a second recombinant DNA that constitutively or inducibly expresses a binding scaffold protein for presentation on the outer surface of the yeast, wherein the cytidine deaminase as expressed by the first recombinant DNA is effective to contribute to a mutagenic process for inducing mutations in the binding scaffold protein of the yeast cell.
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Rolf Karl Swoboda from Upper Darby, PA, age ~69 Get Report