Robert Leveen

51561646, Oct 20, 1992

Feb 4, 1991

7/650985

Harry H. LeVeen - Charleston SC
Robert F. LeVeen - Philadelphia PA

A61F 1320

128832

A bacteriocidal virocidal sponge containing iodine and a surfactant which can be used as a contraceptive and as therapy for vaginitis. It consists of a polyurethane open cell foam impregnated with a surfactant and iodine. A bactericidal tampon containing an iodophor does not induce toxic shock syndrome.

43467083, Aug 31, 1982

Apr 20, 1981

6/255353

Harry H. LeVeen - Charleston SC
Robert F. LeVeen - Philadelphia PA
Eric G. LeVeen - Albany NY

A61M 100

128236

A syringe comprising a cylindrical barrel with a wall at one end with a nozzle and with a threaded actuating rod extending from its other end, the rod having an axial bore and a piston in fluid tight engagement with the inner wall of the barrel is connected to the rod by compressible spring means which is an extension of the rod threads. The rod also carries a collar with threads which mate with the rod threads, and the collar has slots which engage projections on the barrel and prevent movement of the collar relative to the barrel but which permit the collar to be disengaged readily from the barrel. An indicator rod is connected at one end to the piston and is slidable in the bore of the actuating rod. The opposite end of the indicator rod, bearing graduation marks, extends axially outwardly of the actuating rod. Rotation of the actuating rod causes movement of the piston axially of the barrel when the collar is engaged, and as the pressure on fluid within the barrel increases, the spring means compresses causing the indicator rod to extend farther outwardly of the actuating rod and thereby, indicates the fluid pressure.

44481950, May 15, 1984

May 8, 1981

6/261810

Harry H. LeVeen - Charleston SC
Eric G. LeVeen - Albany NY
Robert F. LeVeen - Philadelphia PA

A61M 2902

128344

A balloon catheter is formed by blow molding an elongated polyurethane tube so that one section of the tube has a thinned cross sectional balloon area between the distal end of tube which is sealed and its open proximal end. The balloon portion which is positioned adjacent the distal end has a thinner cross sectional area which allows a balloon to be formed if a fluid is introduced into the catheter by a syringe apparatus which is adapted to be attached to the lumen by a connection adaptor. A wire guide member is adapted to be inserted through the lumen for stretching the catheter when it is inserted into a blood vessel to stiffen the catheter and position it in a proper position. The wire guide member may also be mitred at predetermined intervals to determine the position of the catheter within the blood vessel.

44468679, May 8, 1984

Dec 31, 1981

6/336085

Robert F. Leveen - Philadelphia PA
Eric G. Leveen - Houston TX

A61M 2902

128344

A novel balloon catheter apparatus for treatment of atherosclerotic occlusions within the cardiovascular system, comprising a catheter defining a through-going lumen, a fluid supply syringe attached to one end of the catheter for supplying fluid through the lumen, and a balloon attached to the other end of the catheter which is inflatable by forcing fluid through the lumen. A pulse generator is also attached to the catheter for generating pressure pulses in the fluid through the lumen, which pulses cause the balloon to sharply expand and contract at intervals. The pulse generator includes a pulse syringe communicating with the lumen, a spring-driven ram to contact the piston of the pulse syringe, and a cam rotor to move the ram away from the piston, thereby compressing the spring unitl the cam rotates further and the ram is released to strike the piston. When the balloon catheter is inserted in the cardiovascular system of the patient and guided to the occlusive site, the balloon is first inflated by the supply syringe until the balloon contacts the occlusive material, and then one or more pulses may be applied by the pulse generator through the fluid to rapidly expand and contract the balloon. Since the occlusive material is much more brittle than the surrounding wall, the wall expands in response to the pressure pulses while the occlusive material cracks and separates from the wall to be removed through normal cardiovascular processes.

43677398, Jan 11, 1983

Apr 20, 1981

6/255352

Harry H. LeVeen - Charleston SC
Eric G. LeVeen - Albany NY
Robert F. LeVeen - Philadelphia PA

A61M 100

128236

A syringe comprising a cylindrical barrel with a wall at one end with a nozzle and with a threaded actuating rod extending from its other end, the rod carrying a piston in fluid tight engagement with the inner wall of the barrel. The rod also carries a collar with threads which mate with the rod threads, and the collar has slots which engage projections on the barrel and prevent movement of the collar relative to the barrel but which permit the collar to be disengaged readily from the barrel. A manually engageable knob is rotatably mounted on the rod at its end remote from the piston and is interconnected with the rod by a compressible, spiral spring. A ratchet wheel is mounted on the rod so as to rotate therewith and is adjacent the knob. The knob carries a spring biased pawl in the form of a tooth which is engageable with the ratchet wheel teeth. As the pressure on the fluid in the barrel is increased, the spring is compressed and the knob rotates with respect to the rod causing the pawl to assume a position dependent on the pressure.

48202983, Apr 11, 1989

Nov 20, 1987

7/123367

Eric G. Leveen - Charleston SC
Robert F. Leveen - Philadelphia PA

A61F 206
A61F 202
A61B 1704

623 1

A medical stent for use in an aneurysm constructed with a flexible tubular body formed from a medical thermoplastic in the form of a helix. The flexible tubular body defines a lumen and the body is adapted to assume a substantial linear configuration when mounted on a stylet with the material of the body having a recovery memory which causes it to assume a helical configuration when it is removed from the stylet. The body is provided with strands which are connected to adjacent loops of the helix and extend in the space defined by each coil of the helix to allow clot and ingrowth of tissue to seal off the dilated portion of the vessel.

45295905, Jul 16, 1985

Dec 27, 1982

6/453795

Robert F. LeVeen - Philadelphia PA
Eric G. LeVeen - Charleston SC

A61K 3512
A61K 3900

424 95

A process for the production of tumor angiogenetic factor and the production of antigens from a purified angiogenetic factor is shown in the present invention. The production of tumor angiogenetic factor is accomplished by injecting a material of a suitable composition to initiate production of fluid in the cavity of a living animal by inciting an inflammatory response in the cavity tissues, which response is characterized by the production of granulation tissue comprised mostly of new capillaries. After the body cavity is partly filled with the exudate, the fluid is tapped out of the cavity and purified to yield angiogenetic factor. The production of antigens is accomplished by dissolving the purified angiogenetic factor in an equal volume of distilled water, reacting the dissolved angiogenetic factor in the distilled water with a gluteraldehyde solution for at least twelve (12) hours and lyophilizing resulting mixture for storage. Animals injected with the product produce antibodies which react with the purified angiogenetic factor.

49684396, Nov 6, 1990

Oct 13, 1988

7/257062

Harry H. Leveen - Charleston SC
Eric G. Leveen - Charleston SC
Robert F. LeVeen - Philadelphia PA

Medicinal Developments, Inc. - Las Vegas NV

C02F 168

210764

A canteen containing an iodine polyurethane complex open cell foam sponge for sterilization of water contained in the canteen.