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Robert A Hallewell

from Palo Alto, CA
Age ~74
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Related to:
Henry L Hallewell, 25
Connected to:
Karla Hallewell, 58Thomas E Hallewell, 53Jennifer Hallex, 52Andy Halley, 41Catherine Halley, 46Chuck A Halley, 42Dalene D Halley, 73Diana Halley, 75Doris A Halley, 100Douglas S Halley, 55

Robert Hallewell Phones & Addresses

  • 1118 Harker Ave, Palo Alto, CA 94301
  • Queen Creek, AZ
  • San Tan Valley, AZ
  • 527 Contada Cir, Danville, CA 94526
  • 42 August Aly, San Francisco, CA 94133
  • 1916 Mason St, San Francisco, CA 94133
  • 1922 Mason St, San Francisco, CA 94133
  • 1924 Mason St, San Francisco, CA 94133
  • Santa Clara, CA
  • San Rafael, CA

Business Records

Name / Title
Company / Classification
Phones & Addresses
Robert A. Hallewell
President
ATROPOS GENETIC ENGINEERING, INC
1922 Mason St, San Francisco, CA 94133

Publications

Us Patents

Manganese Superoxide Dismutase Cloning And Expression In Microoganisms

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US Patent:
6830906, Dec 14, 2004
Filed:
Jun 11, 2001
Appl. No.:
09/878589
Inventors:
Robert Alexander Hallewell - San Francisco CA
Graeme Ian Bell - San Francisco CA
Guy Towns Mullenbach - Oakland CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C12N 902
US Classification:
435189, 43525233, 43525421
Abstract:
Methods and compositions are provided for the production of human manganese superoxide dismutase and a protocol for enhancing efficiency of expression. The gene encoding for human manganese superoxide dismutase was isolated and inserted into a vector in conjunction with a synthetic linker which provides for enhanced efficiency in translation. strain HB101 containing the plasmid Nco5AHSODm was deposited at the A. T. C. C. on Oct. 3, 1986 and given Accession No. 67191.

Superoxide Dismutase Cloning And Expression In Microorganisms

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US Patent:
20030104594, Jun 5, 2003
Filed:
Nov 2, 2001
Appl. No.:
10/052792
Inventors:
Robert Hallewell - San Francisco CA, US
Guy Mullenbach - Oakland CA, US
Assignee:
Chiron Corporation
International Classification:
C12N009/02
C07H021/04
C12P021/02
C12N001/21
C12N001/18
C12N015/74
US Classification:
435/189000, 435/252300, 435/254200, 435/069100, 435/320100, 536/023200
Abstract:
Methods and compositions are provided for the production of human superoxide dismutase and a novel protocol for enhancing efficiency of expression. The gene encoding for human superoxide dismutase is isolated and inserted into a vector in conjunction with a synthetic linker which provides for enhanced efficiency in translation.

Active Site Modified Protease .Alpha.-1-Antitrypsin Inhibitors

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US Patent:
47329734, Mar 22, 1988
Filed:
Jun 14, 1984
Appl. No.:
6/620408
Inventors:
Philip J. Barr - Orinda CA
Robert A. Hallewell - San Francisco CA
Steven Rosenberg - Oakland CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C07K 1300
US Classification:
530350
Abstract:
Proteinaceous composition are provided which inhibit naturally occurring serine proteases. Particularly, an amino acid sequence analogous to human. alpha. sub. 1 -antitrypsin is modified at the active site while maintaining protease inhibition. The methionine at the active site is substituted with an oxidatively stable amino acid, while other amino acids may also be changed, added or deleted, particularly at the termini. The yeast strains AB103. 1 (pCl/PH05ATi(Val) and AB110 (pCl/1GAPATi(Val) were deposited at the A. T. C. C. on June 18, 1984 and given Accession Nos. 20711 and 20712, respectively.

Manganese Superoxide Dismutase Cloning And Expression In Microorganisms

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US Patent:
63260034, Dec 4, 2001
Filed:
Oct 14, 1986
Appl. No.:
6/918534
Inventors:
Robert Alexander Hallewell - San Francisco CA
Graeme Ian Bell - San Francisco CA
Guy Towns Mullenbach - Oakland CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
A61K 3844
C12N 902
US Classification:
424 944
Abstract:
Methods and compositions are provided for the production of human manganese superoxide dismutase and a protocol for enhancing efficiency of expression. The gene encoding for human manganese superoxide dismutase was isolated and inserted into a vector in conjunction with a synthetic linker which provides for enhanced efficiency in translation. E. coli strain HB101 containing the plasmid Nco5AHSODm was deposited at the A. T. C. C. on Oct. 3, 1986 and given Accession No. 67191.

Superoxide Dismutase Analogs Having Novel Binding Properties

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US Patent:
51716801, Dec 15, 1992
Filed:
Aug 1, 1990
Appl. No.:
7/561442
Inventors:
Guy T. Mullenbach - Oakland CA
Robert A. Hallewell - San Francisco CA
Pablo Valenzuela - San Francisco CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C12N 902
C12N 121
C12N 114
C12N 1553
US Classification:
435189
Abstract:
Superoxide dismutase (SOD) analogs whose amino acid sequence includes a heterologous peptide domain such as the RGDX tetrapeptide found in fibronectin or the LGGAKQAGDV decapeptide found in fibrinogen that enables the analog to bind to a moiety that is normally present at sites of desired SOD therapy. The domain is incorporated into the SOD sequence in a manner in which it is available to interact with such moieties but does not destroy the enzymatic activity of the molecule. The inclusion of the domain enables the analog to more readily access the target tissue upon which it is to act and/or increase the corporeal half-life of the molecule.

Genetic Modification Of Superoxide Dismutase To Increase Expression In Microorganisms

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US Patent:
56911394, Nov 25, 1997
Filed:
Apr 21, 1995
Appl. No.:
8/426278
Inventors:
Robert A. Hallewell - San Francisco CA
Guy T. Mullenbach - Oakland CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C12Q 168
C12P 2102
C12N 900
C12N 1566
US Classification:
435 6
Abstract:
Methods and compositions are provided for the production of human superoxide dismutase and a novel protocol for enhancing efficiency of expression. The gene encoding for human superoxide dismutase is isolated and inserted into a vector in conjunction with a synthetic linker which provides for enhanced efficiency in translation.

Polypeptides Of Human Copper/Zinc Superoxide Dimutase

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US Patent:
50665910, Nov 19, 1991
Filed:
Nov 16, 1987
Appl. No.:
7/121212
Inventors:
Robert A. Hallewell - San Francisco CA
Guy T. Mullenbach - Oakland CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C12N 902
C12N 1503
US Classification:
435189
Abstract:
Methods and compositions are provided for the production of human copper/zinc superoxide dimutase (SOD) polypeptides in microorganisms. Bacterially produced human CuZn SOD polypeptides are provided. E. coli strain D1210 (pSODX8) was deposited at the A. T. C. C. on Sept. 27, 1983 and given Accession No. 39453. Yeast strain 2150-2-3 (pCl/1GAPSOD) and E. coli strains D1210 (pSOD11) and D1210 (pS2OR) were deposited at the A. T. C. C. on May 9, 1984, and were given Accession Nos. 20708, 39679 and 39680, respectively.

Dna Encoding Human Cytoplasmic Cu/Zn Superoxide Dismutase

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US Patent:
56291892, May 13, 1997
Filed:
Mar 16, 1994
Appl. No.:
8/213573
Inventors:
Robert A. Hallewell - San Francisco CA
Guy T. Mullenbach - Oakland CA
Assignee:
Chiron Corporation - Emeryville CA
International Classification:
C12N 902
C12N 1553
C12N 1566
C07H 2104
US Classification:
435189
Abstract:
Methods and compositions are provided for the production of human superoxide dismutase and a novel protocol for enhancing efficiency of expression. The gene encoding for human superoxide dismutase is isolated and inserted into a vector in conjunction with a synthetic linker which provides for enhanced efficiency in translation. E. coli strain D1210 (pSODX8) was deposited at the A. T. C. C. on Sep. 27, 1983 and given Accession No. 39453. Yeast strain 2150-2-3 (pC1/1GAPSOD) and E. coli strains D1210 (pSOD11) and D1210 (pS2OR) were deposited at the A. T. C. C. on May 9, 1984, and given Accession Nos. 20708, 39679 and 39,680, respectively.
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Robert A Hallewell from Palo Alto, CA, age ~74 Get Report