Inventors:
Michael R. Boyd - Ijamsville MD
John H. Cardellina - Walkersville MD
Kirk P. Manfredi - Frederick MD
John W. Blunt - Christchurch, NZ
Lewis K. Pannell - Silver Spring MD
James B. McMahon - Frederick MD
Robert J. Gulakowski - Frederick MD
Gordon M. Cragg - Bethesda MD
Gerhard Bringmann - Wurzburg, DE
Duncan Thomas - Corvallis OR
Johnson Jato - Yaounde, CM
Assignee:
The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC
International Classification:
A61K 3147
C07D40110
Abstract:
The present invention provides new antiviral compounds, i. e. , michellamines and derivatives and pharmacologically acceptable salts thereof, methods for isolating such antiviral compounds from a plant species of the genus Ancistrocladus, antiviral compositions containing such antiviral compounds, and methods of using such antiviral compounds for treating patients with viral infections. The antiviral compounds of the present invention inhibit the reproduction and cytopathicity of human acquired immunodeficiency viruses.