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Robert M Grotzfeld

from Encinitas, CA
Age ~60
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Also known as:
Robert Martin Grotzfeld, Robert R Grotzfeld
Connected to:
Joyce M Grotzinger, 79Martin P Grotzinger, 65Ronald A Grotzinger, 75Michael H Grotzke, 72Beth I Groubert, 64Nicholas F Groudas, 62Stephanie M Groudle, 34Vlado Grouev, 40Andre Groulx, 86Eric A Groulx, 52

Robert Grotzfeld Phones & Addresses

  • Encinitas, CA
  • Carlsbad, CA
  • San Diego, CA
  • Boston, MA
  • New Haven, CT
  • Cambridge, MA

Publications

Us Patents

Substituted 3-Carboxamido Isoxazoles As Kinase Modulators

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US Patent:
7767670, Aug 3, 2010
Filed:
Nov 15, 2004
Appl. No.:
10/989623
Inventors:
Shamal A. Mehta - San Diego CA, US
Robert M. Grotzfeld - Carlsbad CA, US
Zdravko V. Milanov - San Diego CA, US
Andiliy G. Lai - San Diego CA, US
Hitesh K. Patel - Encinitas CA, US
David J. Lockhart - Del Mar CA, US
Assignee:
Ambit Biosciences Corporation - San Diego CA
International Classification:
C07D 215/14
C07D 217/16
C07D 413/12
C07D 261/14
C07D 261/08
C07D 239/26
C07D 241/12
C07D 473/34
C07D 237/28
C07D 487/04
C07D 513/04
C07D 417/12
C07D 413/14
C07D 455/02
A61K 31/4709
A61K 31/4725
A61K 31/4375
A61K 31/422
A61K 31/4402
A61K 31/4406
A61K 31/4965
A61K 31/506
A61K 31/52
A61K 31/502
A61K 31/5025
A61K 31/429
A61K 31/5377
A61P 35/04
A61P 35/02
A61P 29/00
A61P 9/00
US Classification:
5142322, 546169, 546135, 546145, 5462721, 548247, 548151, 548204, 544405, 544310, 544316, 544277, 544238, 544328, 544236, 544122, 544300, 544321, 514314, 514300, 514307, 514378, 514340, 51425505, 514274, 5142632, 514248, 514256, 514366, 514365, 514270, 514272
Abstract:
The invention provides methods and compositions for treating conditions mediated by various kinases wherein substituted 3-carboxamido isoxazoles compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.

Heterocyclic Compounds And Uses Thereof

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US Patent:
20040242673, Dec 2, 2004
Filed:
May 17, 2004
Appl. No.:
10/847897
Inventors:
David Lockhart - Del Mar CA, US
Hitesh Patel - Encinitas CA, US
Shamal Mehta - San Diego CA, US
Zdravko Milanov - San Diego CA, US
Robert Grotzfeld - Carlsbad CA, US
Andiliy Lai - San Diego CA, US
Assignee:
Ambit Biosciences Corporation - San Diego CA
International Classification:
A61K031/381
US Classification:
514/448000
Abstract:
The invention provides compounds having the thiophene or furan skeleton and uses thereof. The invention provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects. Kits comprising the compounds of the invention are also provided. The compounds and compositions disclosed herein are preferably used in the treatment of neurodegenerative diseases, cardiovascular diseases, proliferative diseases, and visual disorders. In particular, methods and compositions for the treatment of stroke are disclosed herein.

Heterocyclic Compounds And Uses Thereof

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US Patent:
20040248957, Dec 9, 2004
Filed:
May 17, 2004
Appl. No.:
10/848521
Inventors:
David Lockhart - Del Mar CA, US
Hitesh Patel - Encinitas CA, US
Shamal Mehta - San Diego CA, US
Zdravko Milanov - San Diego CA, US
Robert Grotzfeld - Carlsbad CA, US
Andiliy Lai - San Diego CA, US
Assignee:
Ambit Biosciences Corporation - San Diego CA
International Classification:
A61K031/4178
US Classification:
514/396000, 514/397000, 514/217090, 514/227500, 514/235500, 514/254050, 514/326000, 514/365000, 514/374000
Abstract:
The invention provides compounds having the imidazole, oxazole, or thiazole skeleton and uses thereof. The compounds described herein bind to phosphodiesterase 6D. The compounds disclosed herein can be used to modulate the activity of phosphodiesterase 6. The invention provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects. Kits comprising the compounds of the invention are also provided.

Amide Derivatives As Abl Modulators

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US Patent:
20050148605, Jul 7, 2005
Filed:
Nov 15, 2004
Appl. No.:
10/989745
Inventors:
Robert Grotzfeld - Carlsbad CA, US
Hitesh Patel - Encinitas CA, US
Shamal Mehta - San Diego CA, US
Zdravko Milanov - San Diego CA, US
Andiliy Lai - San Diego CA, US
David Lockhart - Del Mar CA, US
International Classification:
A61K031/52
A61K031/517
US Classification:
514263200, 514266230
Abstract:
The invention provides methods and compositions for treating conditions mediated by abl wherein derivatives of amide compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.

Conjugated Small Molecules

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US Patent:
20050153371, Jul 14, 2005
Filed:
Jan 7, 2005
Appl. No.:
11/031638
Inventors:
Robert Grotzfeld - Carlsbad CA, US
Zdravko Milanov - San Diego CA, US
Hitesh Patel - Encinitas CA, US
Andiliy Lai - San Diego CA, US
Shamal Mehta - San Diego CA, US
David Lockhart - Del Mar CA, US
International Classification:
C12Q001/68
G01N033/53
C07H019/04
A61K031/7076
A61K031/4188
A61K031/52
A61K031/506
A61K031/4745
C07D498/02
US Classification:
435007500, 514047000, 514252170, 514275000, 514292000, 514393000, 514234200, 514253060, 514263200, 536026100, 544277000, 544330000, 544284000, 548304100, 514218000, 540575000
Abstract:
Provided herein are linker compounds and conjugates that include the linker compounds. In one embodiment, the linker compounds comprise 2 or 3 residues of 6-aminohexanoic acid and optionally 7-10 residues of polyethyleneglycol (PEG). The linker compounds are useful in forming conjugates with one or more components useful in biopharmaceutical or bioanalytical applications. In particular, the biopharmaceutically useful compounds are kinase inhibitors. The conjugates described herein have utility in a variety of diagnostic, separation, and therapeutic applications.

Pyrrolopyrimidine Derivatives And Analogs And Their Use In The Treatment And Prevention Of Diseases

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US Patent:
20050153989, Jul 14, 2005
Filed:
Jan 13, 2005
Appl. No.:
11/036241
Inventors:
Robert Grotzfeld - Carlsbad CA, US
Hitesh Patel - Encinitas CA, US
Shamal Mehta - San Diego CA, US
Zdravko Milanov - San Diego CA, US
Andiliy Lai - San Diego CA, US
David Lockhart - Del Mar CA, US
International Classification:
A61K031/519
A61K031/52
US Classification:
514260100, 514263400, 514265100
Abstract:
Described herein are compounds and compositions for modulating kinase activity, and methods for modulating kinase activity using the compounds and compositions. Also described herein are methods of using the compounds and/or compositions in the treatment and prevention of a variety of diseases and unwanted conditions in subjects.

Urea Derivatives As Kinase Modulators

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US Patent:
20050165024, Jul 28, 2005
Filed:
Nov 15, 2004
Appl. No.:
10/989824
Inventors:
Zdravko Milanov - San Diego CA, US
Hitesh Patel - Encinitas CA, US
Robert Grotzfeld - Carlsbad CA, US
Shamal Mehta - San Diego CA, US
Andiliy Lai - San Diego CA, US
David Lockhart - Del Mar CA, US
International Classification:
A61K031/52
A61K031/517
A61K031/503
A61K031/4709
C07D473/10
C07D487/04
C07D413/02
US Classification:
514248000, 514263200, 514266200, 514314000, 514378000, 544234000, 544277000, 546169000, 548245000
Abstract:
The invention provides methods and compositions for treating conditions mediated by various kinases wherein derivatives of urea compounds are employed. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.

Urea Derivatives As Abl Modulators

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US Patent:
20050165031, Jul 28, 2005
Filed:
Nov 15, 2004
Appl. No.:
10/989814
Inventors:
Robert Grotzfeld - Carlsbad CA, US
Shamal Mehta - San Diego CA, US
Zdravko Milanov - San Diego CA, US
Andiliy Lai - San Diego CA, US
David Lockhart - Del Mar CA, US
International Classification:
A61K031/52
A61K031/519
A61K031/517
US Classification:
514263200, 514265100, 514266200
Abstract:
The invention provides methods and compositions for treating conditions mediated by Bcr-Abl. The invention also provides methods of using the compounds and/or compositions in the treatment of a variety of diseases and unwanted conditions in subjects.
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Robert M Grotzfeld from Encinitas, CA, age ~60 Get Report