Robert L Bugianesi

6528531, Mar 4, 2003

Nov 10, 2000

09/709961

Danqing D. Feng - Branchburg Township NJ
Mitree M. Ponpipom - Branchburg NJ
Xiaoxia Qian - New York NY
Michael H. Fisher - Ringoes NJ
Matthew J. Wyvratt - Mountainside NJ
Robert L. Bugianesi - Brick NJ

Merck Co., Inc. - Rahway NJ

A61K 31445

514318, 514326, 514327, 514352, 514354, 546194, 546208, 546210, 546223

Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.

42282748, Oct 14, 1980

Jul 10, 1978

5/922897

Mitree M. Ponpipom - North Plainfield NJ
Robert L. Bugianesi - Colonia NJ
Philippe L. Durette - New Providence NJ
Howard M. Katzen - North Plainfield NJ
Tsung-Ying Shen - Westfield NJ

Merck & Co., Inc. - Rahway NJ

C07H 506
C07H 508

536 4

The invention disclosed herein relates to novel 1-deoxy-glycopyranosides, preferably 1-deoxy-D-mannopyranosides, having in the 1-position of the pyranoside ring an. omega. -aminoalkylthio,. omega. -aminoalkyloxy or. omega. -aminoalkanoylamino substituent; and to novel processes for preparing these 1-substituted-1-deoxy-glycopyranosides starting with the corresponding tetra-O-acetyl-glycopyranosyl bromide or amine. These. omega. -amino(alkylthio, alkyloxy or alkanoylamino)-1-deoxy-glycopyranosides, and in particular 1-[(6'-aminohexyl)thio or oxy]-1-deoxy-D-mannopyranosides, possess insulin-like activity.

53691253, Nov 29, 1994

Mar 19, 1993

8/033913

Gregory D. Berger - Belle Mead NJ
James D. Bergstrom - Neshanic NJ
Tesfaye Biftu - Westfield NJ
Robert L. Bugianesi - Colonia NJ
Robert M. Burk - Laguna Beach CA
Narindar N. Girotra - Old Bridge NJ
C. H. Kuo - South Plainfield NJ
William H. Parsons - Edison NJ
Mitree M. Ponpipom - Branchburg NJ
Lori L. Whiting - West Carrollton OH

Merck & Co., Inc. - Rahway NJ

A61K 31335
C07D31904

514452

This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.

49962035, Feb 26, 1991

Jun 8, 1989

7/362915

Tesfaye Biftu - Parlin NJ
Robert L. Bugianesi - Colonia NJ
Mitree M. Ponpipom - Branchburg NJ
Soumya P. Sahoo - Edison NJ
Chan H. Kuo - South Plainfield NJ

Merck & Co., Inc. - Rahway NJ

C07D40512
C07D41312
A61K 3154
A61K 31495

5142315

The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein R. sup. 4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3,4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio moiety.

50011235, Mar 19, 1991

Jun 8, 1989

7/362907

Tesfaye Biftu - Parlin NJ
Robert L. Bugianesi - Colonia NJ
Mitree M. Ponpipom - Branchburg NJ
Soumya P. Sahoo - Edison NJ
Chan H. Kuo - South Plainfield NJ

Merck & Co., Inc. - Rahway NJ

C07D40504
C07D41312
A61K 3144
A61K 3155

5142352

The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein Ar is a pyridyl, a dimethoxy-pyridyl or dimethoxy-pyrazyl group, R. sup. 4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3,4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio group.

51149613, May 19, 1992

Dec 10, 1990

7/624449

Tesfaye Biftu - Parlin NJ
Robert L. Bugianesi - Colonia NJ
Mitree M. Ponpipom - Branchburg NJ
Soumya P. Sahoo - Edison NJ
Chan H. Kuo - South Plainfield NJ

Merck & Co., Inc. - Rahway NJ

C07D40712
A61K 31415

514397

The present invention is directed to a specifically substituted tetrahydrofuran of the formula (I) ##STR1## wherein R. sup. 4 is an alkylthio, alkylsulfinyl or alkylsulfonyl containing group and at least one of the substituents at positions 3, 4 or 5 contains a heterocyclic, heteroaryl or substituted phenylthio moiety.

57565074, May 26, 1998

Dec 5, 1996

8/760851

Mark Goulet - Westfield NJ
Lin Chu - Scotch Plains NJ
Wallace T. Ashton - Clark NJ
Michael H. Fisher - Ringoes NJ
Matthew J. Wyvratt - Mountainside NJ
Roy G. Smith - Westfield NJ
Robert L. Bugianesi - Colonia NJ
Mitree M. Ponpipom - Branchburg NJ
Yi Tien Yang - Neshanic Station NJ
Peter Lin - Edison NJ

Merck & Co., Inc. - Rahway NJ

A61K 31405
A61K 31495
C07D20910
C07D40306

514255

There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

42294410, Oct 21, 1980

Dec 1, 1978

5/965559

Robert L. Bugianesi - Colonia NJ
Mitree M. Ponpipom - Branchburg NJ
Tsung-Ying Shen - Westfield NJ

Merck & Co., Inc. - Rahway NJ

A61K 31705
C07G 7908

424182

Glycolipid compounds of the formulae ##STR1## wherein R is ##STR2## are useful immunologic adjuvants in vaccines.