Inventors:
Jack D. Barchas - Stanford CA
Glen R. Elliott - Sunnyvale CA
Peter I. Adriaenssens - Palo Alto CA
Robert S. Bitner - Mountain View CA
Stephen S. Bowersox - Menlo Park CA
Laszlo Nadasdi - San Francisco CA
Assignee:
Neurex Corporation - Menlo Park CA
International Classification:
A61K 3144
Abstract:
Compounds of formula I are useful for suppressing appetite, for altering macronutrient preferences, for suppressing obsessive-compulsive behavior, and for inhibiting cravings and substance abuse: ##STR1## wherein R. sub. 1 and R. sub. 3 are each independently H, hydroxy-alkyl, alpha-cyanoalkyl, SO. sub. 3 H, SO. sub. 2 NH. sub. 2, or C(O)R, where R is OH, NH. sub. 2, lower alkoxy, benzyloxy, or aliphatic amino acyl; R. sub. 2 and R. sub. 9 are each independently H, lower alkyl, benzyl, succinyl, or C(O)R. sub. 4, where R. sub. 4 is H, lower alkyl, hydrocarboxy-lower alkylene, or lower alkoxycarboxy-lower alkylene; and R. sub. 5, R. sub. 6, R. sub. 7, and R. sub. 8 are each independently H, halo, lower alkyl, hydroxy, lower alkoxy, or two adjacent radicals form methylenedioxy or ethylenedioxy; with the proviso that R. sub. 1, R. sub. 2, R. sub. 3, R. sub. 5, R. sub. 6, R. sub. 7, R. sub. 8, and R. sub. 9 are not simultaneously H.
