Rishabh M Shetty

20220268768, Aug 25, 2022

Feb 22, 2022

17/677255

- La Jolla CA, US
Paul Rothemund - Pasadena CA, US
Rishabh Shetty - San Diego CA, US
Shane Bowen - Encinitas CA, US
Rachel Galimidi - Encinitas CA, US

G01N 33/543
G01N 33/58
B01L 3/00

Provided herein are structures and methods for detecting one or more analyte molecules present in a sample. In some embodiments, the one or more analyte molecules are detected using one or more supramolecular structures. In some embodiments, the supramolecular structures facilitate binding of a single detector molecule. In some embodiments, the stable state supramolecular structures are configured to provide a signal for analyte molecule detection and quantification. In some embodiments, the signal correlates to a DNA signal, such that detection and quantification of an analyte molecule comprises converting the presence of the analyte molecule into a DNA signal.

20210032775, Feb 4, 2021

Nov 30, 2018

16/762024

- Scottsdale AZ, US
- Pasadena CA, US
Rishabh SHETTY - Tempe AZ, US
Rizal HARIADI - Phoenix AZ, US

C40B 40/06
B01J 19/00

Embodiments of the present disclosure relate generally to single molecule arrays. More particularly, the present disclosure provides materials and methods for generating single molecule arrays using bottom-up self-assembly processes. Materials and methods of the present disclosure can be used to generate single molecule arrays with nanoapertures (e.g., zero mode waveguides) and for carrying out rapid, point-of-care biomolecule detection and quantification.

20200058140, Feb 20, 2020

Mar 2, 2018

16/487535

- Scottsdale AZ, US
Roger Johnson - Phoenix AZ, US
Laimonas Kelbauskas - Gilbert AZ, US
Jeff Houkal - Los Angeles CA, US
Brian Ashcroft - Mesa AZ, US
Dean Smith - Phoenix AZ, US
Hong Wang - Tempe AZ, US
Shih-Hui (Joseph) Chao - Phoenix AZ, US
Rishabh Shetty - Tempe AZ, US
Jakrey Myers - Scottsdale AZ, US
Iniyan Soundappa Elango - Hillsboro OR, US

G06T 11/00
G06T 5/00
G06T 17/00
G06T 5/50
G06T 7/30
G06T 7/194
G01N 15/02
G01N 15/14

Systems and methods of using the same for functional fluorescence imaging of live cells in suspension with isotropic three dimensional (3D) diffraction-limited spatial resolution are disclosed. The method-live cell computed tomography (LCCT)-in-volves the acquisition of a series of two dimensional (2D) pseudo-projection images from different perspectives of the cell that rotates around an axis that is perpendicular to the optical axis of the imaging system. The volumetric image of the cell is then tomographically reconstructed.

20190346361, Nov 14, 2019

Mar 2, 2017

16/082170

- Scottsdale AZ, US
Roger Johnson - Phoenix AZ, US
Laimonas Kelbauskas - Gilbert AZ, US
Jeff Houkal - Los Angeles CA, US
Brian Ashcroft - Mesa AZ, US
Dean Smith - Phoenix AZ, US
Hong Wang - Tempe AZ, US
Shih-Hui Joseph Chao - Phoenix AZ, US
Rishabh Shetty - Tempe AZ, US
Jakrey Myers - Scottsdale AZ, US
Iniyan Soundappa Elango - Hillsboro OR, US

G01N 15/14
G01N 21/47

Systems and methods of using the same for functional fluorescence imaging of live cells in suspension with isotropic three dimensional (3D) diffraction-limited spatial resolution are disclosed. The method-live cell computed tomography (LCCT)-involves the acquisition of a series of two dimensional (2D) pseudo-projection images from different perspectives of the cell that rotates around an axis that is perpendicular to the optical axis of the imaging system. The volumetric image of the cell is then tomographically reconstructed.

20160084750, Mar 24, 2016

Sep 22, 2015

14/861143

- Scottsdale AZ, US
Deirdre Meldrum - Phoenix AZ, US
Rishabh Shetty - Tempe AZ, US
Laimonas Kelbauskas - Gilbert AZ, US
Shih-Hui Chao - Phoenix AZ, US
Roger Johnson - Phoenix AZ, US
Jakrey Myers - Scottsdale AZ, US
Samantha Chan - Tempe AZ, US

G01N 21/05
G02B 21/36
B01L 3/00

Microfluidic devices for 3D hydrodynamic microvortical rotation of at least one live single cell or cell cluster, systems incorporating the devices, and methods of fabricating and using the devices and systems, are provided. A microfluidic chip rotates at least one live single cell or cell cluster in a microvortex about a stable rotation axis perpendicular to an optical axis within a chamber having a trapezoidal cross-sectional shape located below a flow channel. An optical trap may be used to position the cell or cells with the microvortex, and the cell or cells may be subject to live-cell or cell cluster computer tomography imaging.